Alteration of poly(ADP-ribose) metabolism by hyperthermia
| Autor: | Myron K. Jacobson, Gilberto Duran-Torres, Hector Juarez-Salinas |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Hyperthermia
Methylnitronitrosoguanidine Poly Adenosine Diphosphate Ribose Hot Temperature Biophysics Simian virus 40 Biochemistry Environmental stress chemistry.chemical_compound Mice Ribose medicine Animals Molecular Biology Cells Cultured Mice Inbred BALB C Ethanol Nucleoside Diphosphate Sugars Cell Biology Metabolism DNA Fibroblasts medicine.disease Kinetics Cell Transformation Neoplastic chemistry Intracellular |
| Zdroj: | Biochemical and biophysical research communications. 122(3) |
| ISSN: | 0006-291X |
| Popis: | The intracellular levels of poly(ADP-ribose) in cultured mouse cells were increased in response to hyperthermic treatment (43°C). When hyperthermia was combined with other stressful treatments such as with ethanol and/or an alkylating agent, a dramatic synergistic increase in polymer levels was observed. The effect of hyperthermia did not appear to be related to the presence of DNA strand breaks. A possible involvement of poly(ADP-ribose) metabolism in the general cellular response to environmental stress is suggested. |
| Databáze: | OpenAIRE |
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