Role of cAMP signalling in winner and loser effects in crayfish agonistic encounters

Autor:	Akihiro Kanai, Yuto Momohara, Hiroki Minami, Toshiki Nagayama
Rok vydání:	2016
Předmět:	Dominance-Subordination 0106 biological sciences medicine.medical_specialty Memory Long-Term medicine.drug_class Astacoidea 010603 evolutionary biology 01 natural sciences Adenylyl cyclase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Receptors Biogenic Amine Internal medicine Cyclic AMP medicine Agonistic behaviour Animals Receptor Protein kinase A Procambarus clarkii biology Ecology General Neuroscience Crayfish biology.organism_classification Receptor antagonist Cyclic AMP-Dependent Protein Kinases Ganglia Invertebrate Endocrinology chemistry Adenylyl Cyclase Inhibitors 5-HT1 receptor Serotonin Antagonists Psychology 030217 neurology & neurosurgery Signal Transduction
Zdroj:	European Journal of Neuroscience. 44:1886-1895
ISSN:	0953-816X
DOI:	10.1111/ejn.13259
Popis:	For territorial animals, establishment of status-dependent dominance order is essential to maintain social stability. In agonistic encounters of the crayfish Procambarus clarkii, a difference of body length of 3-7% is enough for larger animals to become dominant. Despite a physical disadvantage, small winners of the first pairings were more likely to win subsequent conflicts with larger inexperienced animals. In contrast, the losers of the first pairings rarely won subsequent conflicts with smaller naive animals. Such experiences of previous winning or losing affected agonistic outcomes for a long period. The winner effects lasted more than 2 weeks and the loser effect lasted about 10 days. Injection of 5HT1 receptor antagonist into the dominant animals 15-30 min after establishment of dominance order blocked the formation of the winner effects. In contrast, injection of adrenergic-like octopamine receptor antagonist into subordinate animals blocked the formation of the loser. 5HT1 receptors are negatively coupled to adenylyl cyclase and adrenergic-like octopamine receptors are positively coupled. Consistent with this, dominant animals failed to show the winner effect when injected with pCPT-cAMP, a cAMP analogue, and subordinate animals failed to show a loser effect when injected with adenylyl cyclase inhibitor SQ 22536. These results suggest that an increase and decrease of cAMP concentration is essential in mediating loser and winner effects, respectively. Furthermore, formation of the loser effect was blocked by injection of protein kinase A (PKA) inhibitor H89, suggesting long-term memory of the loser effect is dependent on the cAMP-PKA signalling pathway.
Databáze:	OpenAIRE
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