Cardiovascular Disease Risk in a Large, Population-Based Cohort of Breast Cancer Survivors

Autor: Dominic A.X. Schinagl, Otto Visser, Nicola S. Russell, Jourik A. Gietema, Michael Schaapveld, Naomi B. Boekel, Philip Poortmans, Emiel J. Th. Rutgers, Flora E. van Leeuwen, Berthe M.P. Aleman, Derek H. F. Rietveld, Michel I.M. Versteegh, Jacqueline C.M. Theuws
Přispěvatelé: Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Radiation Oncology, CCA - Clinical Therapy Development, Epidemiology and Data Science, EMGO - Quality of care
Rok vydání: 2016
Předmět:
Cancer Research
Time Factors
Heart disease
Heart Valve Diseases
Myocardial Ischemia
CHILDHOOD
030204 cardiovascular system & hematology
Cohort Studies
0302 clinical medicine
Cause of Death
Antineoplastic Combined Chemotherapy Protocols
FAILURE
Registries
Survivors
Mastectomy
Netherlands
Cause of death
education.field_of_study
Radiation
LONG-TERM SURVIVORS
valvular heart disease
Age Factors
WOMEN
Heart
Middle Aged
CHEMOTHERAPY
Combined Modality Therapy
Women's cancers Radboud Institute for Health Sciences [Radboudumc 17]
Oncology
Cardiovascular Diseases
Chemotherapy
Adjuvant
030220 oncology & carcinogenesis
Cohort
Female
Fluorouracil
RADIOTHERAPY
Cohort study
medicine.medical_specialty
Population
Antineoplastic Agents
HEART-DISEASE
Risk Assessment
03 medical and health sciences
LUNG-CANCER
Breast cancer
Internal medicine
Confidence Intervals
Unilateral Breast Neoplasms
medicine
Humans
Radiology
Nuclear Medicine and imaging
cardiovascular diseases
education
Aged
Heart Failure
Lymphatic Irradiation
business.industry
CAUSE-SPECIFIC MORTALITY
ANTHRACYCLINE
medicine.disease
Surgery
Carcinoma
Intraductal
Noninfiltrating
Methotrexate
Standardized mortality ratio
Cisplatin
business
Zdroj: International Journal of Radiation Oncology, Biology, Physics, 94, 5, pp. 1061-72
International Journal of Radiation Oncology Biology Physics, 94(5), 1061-1072. ELSEVIER SCIENCE INC
Boekel, N B, Schaapveld, M, Gietema, J A, Russell, N S, Poortmans, P, Theuws, J C M, Schinagl, D A X, Rietveld, D H F, Versteegh, M I M, Visser, O, Rutgers, E J T, Aleman, B M P & van Leeuwen, F E 2016, ' Cardiovascular Disease Risk in a Large, Population-Based Cohort of Breast Cancer Survivors ', International journal of radiation oncology, biology, physics, vol. 94, no. 5, pp. 1061-72 . https://doi.org/10.1016/j.ijrobp.2015.11.040
International Journal of Radiation Oncology, Biology, Physics, 94, 1061-72
International Journal of Radiation Oncology-Biology-Physics, 94(5), 1061-1072
International journal of radiation oncology, biology, physics, 94(5), 1061-72. Elsevier Inc.
ISSN: 0360-3016
DOI: 10.1016/j.ijrobp.2015.11.040
Popis: Item does not contain fulltext PURPOSE: To conduct a large, population-based study on cardiovascular disease (CVD) in breast cancer (BC) survivors treated in 1989 or later. METHODS AND MATERIALS: A large, population-based cohort comprising 70,230 surgically treated stage I to III BC patients diagnosed before age 75 years between 1989 and 2005 was linked with population-based registries for CVD. Cardiovascular disease risks were compared with the general population, and within the cohort using competing risk analyses. RESULTS: Compared with the general Dutch population, BC patients had a slightly lower CVD mortality risk (standardized mortality ratio 0.92, 95% confidence interval [CI] 0.88-0.97). Only death due to valvular heart disease was more frequent (standardized mortality ratio 1.28, 95% CI 1.08-1.52). Left-sided radiation therapy after mastectomy increased the risk of any cardiovascular event compared with both surgery alone (subdistribution hazard ratio (sHR) 1.23, 95% CI 1.11-1.36) and right-sided radiation therapy (sHR 1.19, 95% CI 1.04-1.36). Radiation-associated risks were found for not only ischemic heart disease, but also for valvular heart disease and congestive heart failure (CHF). Risks were more pronounced in patients aged /=1997 (ie, anthracyline-based chemotherapy) increased the risk of CHF (sHR 1.35, 95% CI 1.00-1.83). CONCLUSION: Radiation therapy regimens used in BC treatment between 1989 and 2005 increased the risk of CVD, and anthracycline-based chemotherapy regimens increased the risk of CHF.
Databáze: OpenAIRE
Externí odkaz: