Unethical not to Investigate Radiotherapy for COVID-19
| Autor: | Joseph John Bevelacqua, Jerry M. Cuttler, Seyed Mohammad Javad Mortazavi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Coronavirus disease 2019 (COVID-19) Primum non nocere Health Toxicology and Mutagenesis medicine.medical_treatment Encephalopathy Toxicology 03 medical and health sciences 0302 clinical medicine low dose radiation Interim medicine pneumonia Letter to the Editor lung radiotherapy Chemical Health and Safety business.industry General surgery lcsh:RM1-950 Public Health Environmental and Occupational Health Winship Cancer Institute COVID-19 medicine.disease Clinical trial Radiation therapy Pneumonia lcsh:Therapeutics. Pharmacology 030104 developmental biology 030220 oncology & carcinogenesis business |
| Zdroj: | Dose-Response, Vol 18 (2020) Dose-Response |
| ISSN: | 1559-3258 |
| Popis: | The primum non nocere letter by Boon et al. urged caution and careful examination of the evidence and logistics of low-dose radiotherapy in COVID-19 patients. This is exactly what was requested in March and what has occurred since late April 2020 when the first phase I/II clinical trial was approved at the Winship Cancer Institute, Emory University Hospital. The preprint of day-7 interim results by the investigators concluded, “In a small pilot trial of 5 oxygen-dependent patients with COVID-19 pneumonia, low-dose whole-lung radiation led to rapid improvement in clinical status, encephalopathy, and radiographic infiltrates without acute toxicity or worsening the cytokine storm. Low-dose whole-lung radiation appears to be safe, shows early promise of efficacy, and warrants larger prospective trials.” Preliminary results from another clinical trial gave similar results. In conclusion, the authors believe it would be unethical not to investigate radiotherapy as a potential remedy against COVID-19 induced pneumonia |
| Databáze: | OpenAIRE |
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