Sex differences in [11C]ABP688 binding: a positron emission tomography study of mGlu5 receptors
| Autor: | Stephanie G. Scala, Kelly Smart, Natalia Jaworska, Chawki Benkelfat, Michel Boivin, Maria Tippler, Jean R. Séguin, Marco Leyton, Sylvia M. L. Cox |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Pyridines Short Communication Receptor Metabotropic Glutamate 5 Hippocampus Grey matter 030218 nuclear medicine & medical imaging Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Oximes medicine Humans Radiology Nuclear Medicine and imaging Carbon Radioisotopes Prefrontal cortex mGluR5 Sex Characteristics medicine.diagnostic_test business.industry Metabotropic glutamate receptor 5 Gender Brain Binding potential General Medicine Metabotropic glutamate receptors Healthy Volunteers PET Metabotropic receptor Endocrinology medicine.anatomical_structure Positron emission tomography Metabotropic glutamate receptor Positron-Emission Tomography 030220 oncology & carcinogenesis Female business Protein Binding |
| Zdroj: | European Journal of Nuclear Medicine and Molecular Imaging |
| ISSN: | 1619-7089 1619-7070 |
| Popis: | Purpose The purpose of this study was to assess, in a large sample of healthy young adults, sex differences in the binding potential of [11C]ABP688, a positron emission tomography (PET) tracer selective for the metabotropic glutamate type 5 (mGlu5) receptor. Methods High resolution [11C]ABP688 PET scans were acquired in 74 healthy volunteers (25 male, 49 female, mean age 20 ± 3.0). Mean binding potential (BPND = fND * (Bavail / KD)) values were calculated in the prefrontal cortex, striatum, and limbic regions using the simplified reference tissue model with cerebellar grey matter as the reference region. Results [11C]ABP688 BPND was significantly higher in men compared to women in the prefrontal cortex (p |
| Databáze: | OpenAIRE |
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