A metagenome-wide association study of gut microbiome and visceral fat accumulation
Autor: | Xiaojing Ma, Haoyong Yu, Yuqian Bao, Xiaomin Nie, Gianni Panagiotou, Yun Shen, Jiarui Chen, Yueqiong Ni |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
VFA
visceral fat area GPR43 G-protein coupled receptor 43 BMI body mass index Cr creatinine Physiology AST aspartate aminotransferase Disease SCFAs short chain fatty acids Biochemistry 0302 clinical medicine WBC white blood cell count WHR waist-to-hip ratio Structural Biology Medicine Visceral fat 0303 health sciences TG triglyceride FMT fecal microbiota transplantation SFA subcutaneous fat area LSG laparoscopic sleeve gastrectomy UA uric acid Computer Science Applications 030220 oncology & carcinogenesis TCA tricarboxylic acid cycle Research Article Biotechnology MSG monosodium glutamate Waist FDR false discovery rate HDL high-density lipoprotein cholesterol lcsh:Biotechnology 2hCP 2-hour C-peptide Biophysics DBP diastolic blood pressure 03 medical and health sciences 2hPG 2-hour plasma glucose ALT alanine aminotransferase lcsh:TP248.13-248.65 Genetics Carbohydrate fermentation FPG fasting plasma glucose Obesity Risk factor BCAAs branched chain amino acids ComputingMethodologies_COMPUTERGRAPHICS 030304 developmental biology Gut microbiome business.industry SBP systolic blood pressure CoDA Compositional Data Analysis LDL low-density lipoprotein cholesterol medicine.disease TC total cholesterol Laparoscopic sleeve gastrectomy FCp fasting C-peptide Metagenomics LPS lipopolysaccharides business MRI magnetic resonance imaging Body mass index HbA1c glycated hemoglobin A1c |
Zdroj: | Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 2596-2609 (2020) Computational and Structural Biotechnology Journal |
ISSN: | 2001-0370 |
Popis: | Graphical abstract Purpose Visceral fat is an independent risk factor for metabolic and cardiovascular disease. The study aimed to investigate the associations between gut microbiome and visceral fat. Methods We recruited 32 obese adults and 30 healthy controls at baseline. Among the obese subjects, 14 subjects underwent laparoscopic sleeve gastrectomy (LSG) and were followed 6 months after surgery. Abdominal visceral fat area (VFA) and subcutaneous fat area (SFA) were measured by magnetic resonance imaging. Waist, hipline, waist-to-hip ratio (WHR) and body mass index (BMI) were included as simple obese parameters. Gut microbiome was analyzed by metagenomic sequencing. Results Among the obese parameters, VFA had the largest number of correlations with the species that were differentially enriched between obese and healthy subjects, following by waist, WHR, BMI, hipline, and SFA. Within the species negatively correlated with VFA, Eubacterium eligens had the strongest correlation, following by Clostridium citroniae, C. symbiosum, Bacteroides uniformis, E. ventriosum, Ruminococcaceae bacterium D16, C. hathewayi, etc. C. hathewayi and C. citroniae were increased after LSG. Functional analyses showed that among all the obese parameters, VFA had strongest correlation coefficients with the obesity-related microbial pathways. Microbial pathways involved in carbohydrate fermentation and biosynthesis of L-glutamate and L-glutamine might contribute to visceral fat accumulation. Conclusions Visceral fat was more closely correlated with gut microbiome compared with subcutaneous fat, suggesting an intrinsic connection between gut microbiome and metabolic cardiovascular diseases. Specific microbial species and pathways which were closely associated with visceral fat accumulation might contribute to new targeted therapies for metabolic disorders. |
Databáze: | OpenAIRE |
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