A metagenome-wide association study of gut microbiome and visceral fat accumulation

Autor: Xiaojing Ma, Haoyong Yu, Yuqian Bao, Xiaomin Nie, Gianni Panagiotou, Yun Shen, Jiarui Chen, Yueqiong Ni
Jazyk: angličtina
Rok vydání: 2020
Předmět:
VFA
visceral fat area

GPR43
G-protein coupled receptor 43

BMI
body mass index

Cr
creatinine

Physiology
AST
aspartate aminotransferase

Disease
SCFAs
short chain fatty acids

Biochemistry
0302 clinical medicine
WBC
white blood cell count

WHR
waist-to-hip ratio

Structural Biology
Medicine
Visceral fat
0303 health sciences
TG
triglyceride

FMT
fecal microbiota transplantation

SFA
subcutaneous fat area

LSG
laparoscopic sleeve gastrectomy

UA
uric acid

Computer Science Applications
030220 oncology & carcinogenesis
TCA
tricarboxylic acid cycle

Research Article
Biotechnology
MSG
monosodium glutamate

Waist
FDR
false discovery rate

HDL
high-density lipoprotein cholesterol

lcsh:Biotechnology
2hCP
2-hour C-peptide

Biophysics
DBP
diastolic blood pressure

03 medical and health sciences
2hPG
2-hour plasma glucose

ALT
alanine aminotransferase

lcsh:TP248.13-248.65
Genetics
Carbohydrate fermentation
FPG
fasting plasma glucose

Obesity
Risk factor
BCAAs
branched chain amino acids

ComputingMethodologies_COMPUTERGRAPHICS
030304 developmental biology
Gut microbiome
business.industry
SBP
systolic blood pressure

CoDA
Compositional Data Analysis

LDL
low-density lipoprotein cholesterol

medicine.disease
TC
total cholesterol

Laparoscopic sleeve gastrectomy
FCp
fasting C-peptide

Metagenomics
LPS
lipopolysaccharides

business
MRI
magnetic resonance imaging

Body mass index
HbA1c
glycated hemoglobin A1c
Zdroj: Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 2596-2609 (2020)
Computational and Structural Biotechnology Journal
ISSN: 2001-0370
Popis: Graphical abstract
Purpose Visceral fat is an independent risk factor for metabolic and cardiovascular disease. The study aimed to investigate the associations between gut microbiome and visceral fat. Methods We recruited 32 obese adults and 30 healthy controls at baseline. Among the obese subjects, 14 subjects underwent laparoscopic sleeve gastrectomy (LSG) and were followed 6 months after surgery. Abdominal visceral fat area (VFA) and subcutaneous fat area (SFA) were measured by magnetic resonance imaging. Waist, hipline, waist-to-hip ratio (WHR) and body mass index (BMI) were included as simple obese parameters. Gut microbiome was analyzed by metagenomic sequencing. Results Among the obese parameters, VFA had the largest number of correlations with the species that were differentially enriched between obese and healthy subjects, following by waist, WHR, BMI, hipline, and SFA. Within the species negatively correlated with VFA, Eubacterium eligens had the strongest correlation, following by Clostridium citroniae, C. symbiosum, Bacteroides uniformis, E. ventriosum, Ruminococcaceae bacterium D16, C. hathewayi, etc. C. hathewayi and C. citroniae were increased after LSG. Functional analyses showed that among all the obese parameters, VFA had strongest correlation coefficients with the obesity-related microbial pathways. Microbial pathways involved in carbohydrate fermentation and biosynthesis of L-glutamate and L-glutamine might contribute to visceral fat accumulation. Conclusions Visceral fat was more closely correlated with gut microbiome compared with subcutaneous fat, suggesting an intrinsic connection between gut microbiome and metabolic cardiovascular diseases. Specific microbial species and pathways which were closely associated with visceral fat accumulation might contribute to new targeted therapies for metabolic disorders.
Databáze: OpenAIRE