Clozapine induced tubulointerstitial nephritis in a patient with paranoid schizophrenia
| Autor: | Ravi Parekh, Dilraj Sahota, Bernie Colaco, Zozik Fattah |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Paranoid schizophrenia medicine.medical_specialty medicine.medical_treatment Article Internal medicine mental disorders medicine Humans Antipsychotic Acute tubulointerstitial nephritis Clozapine Schizophrenia Paranoid medicine.diagnostic_test business.industry General Medicine Middle Aged medicine.disease Endocrinology Schizophrenia Prednisolone Nephritis Interstitial Renal biopsy Complication business medicine.drug Antipsychotic Agents |
| Zdroj: | BMJ case reports. 2014 |
| ISSN: | 1757-790X |
| Popis: | We describe the development of tubulointerstitial nephritis after starting clozapine therapy in a patient with treatment-resistant schizophrenia. A 54-year-old mixed-race patient with a longstanding history of paranoid schizophrenia was started on the antipsychotic clozapine. Two months after starting clozapine he developed fevers, cough and acute renal failure which initially responded to 7 days of prednisolone but recurred after completing the steroid course. Renal biopsy confirmed acute tubulointerstitial nephritis and he was started on a course of steroids with renal recovery in 72 h. Clozapine was later stopped. This case highlights a serious and potential life-threatening complication of an important antipsychotic used in treatment-resistant schizophrenia. |
| Databáze: | OpenAIRE |
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