Circulating Lipoprotein-associated Phospholipase A2 in High-grade Carotid Stenosis: A New Biomarker for Predicting Unstable Plaque
| Autor: | Pierre-Edouard Magnan, A. Boudes, E. Sarlon, Benjamin Thevenin, C. Squarcioni, Youssef Bennis, Marie-Dominique Piercecchi-Marti, F. Nicoli, Michel A. Bartoli, Gabrielle Sarlon-Bartoli, Florence Sabatier, Christophe Buffat, Laurent Arnaud, Françoise Dignat-George |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Lp-PLA2 Carotid endarterectomy Asymptomatic Unstable plaque Interquartile range Internal medicine Carotid artery disease medicine Humans Carotid Stenosis Prospective Studies Prospective cohort study Aged Endarterectomy Aged 80 and over Medicine(all) Endarterectomy Carotid High-grade carotid stenosis biology business.industry C-reactive protein Middle Aged medicine.disease Atherosclerosis Stenosis C-Reactive Protein Cross-Sectional Studies 1-Alkyl-2-acetylglycerophosphocholine Esterase biology.protein Cardiology Female Surgery Nervous System Diseases medicine.symptom business Cardiology and Cardiovascular Medicine Biomarkers |
| Zdroj: | European Journal of Vascular and Endovascular Surgery. 43(2):154-159 |
| ISSN: | 1078-5884 |
| DOI: | 10.1016/j.ejvs.2011.10.009 |
| Popis: | Objective To test plasma levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) in patients with high-grade carotid stenosis according to plaque histology. Methods This cross-sectional single-centre study included patients with ≥70% North American Symptomatic Carotid Endarterectomy Trial (NASCET) carotid stenosis, who were treated surgically. Serum Lp-PLA2 and high-sensitivity C-reactive protein (hs-CRP) were determined on the day of surgery. Histopathological analysis classified carotid plaque as stable or unstable, according to AHA classification. Results Of the 42 patients (mean age 70.4 ± 10.5 years; 67% men), neurological symptoms were present in 16 (38%). Unstable plaques were found in 23 (55%). Median plasma level of Lp-PLA2 was significantly higher in patients with unstable plaque compared to those with stable plaque (222.4 (174.9–437.5) interquartile range (IQR) 63.5 vs. 211.1 (174.9–270.6) IQR 37.2 ng ml−1; p = 0.02). Moreover, median Lp-PLA2 level were higher in asymptomatic patients with unstable plaque (226.8 ng ml−1 (174.9–437.5) IQR 76.8) vs. stable plaque (206.9 ng ml−1 (174.9–270.6) IQR 33.7; p = 0.16). Logistic regression showed that only the neurological symptoms (OR = 30.9 (3.7–244.6); p |
| Databáze: | OpenAIRE |
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