Effects of isopropyl alcohol, ethanol, and polyethylene glycol/industrial methylated spirits in the treatment of acute phenol burns
Autor: | Ralph B. Leonard, Timothy H. McCalmont, David M Hunter, Beverly L Timerding, Earl Schwartz |
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Rok vydání: | 1992 |
Předmět: |
medicine.medical_specialty
Swine Biopsy Alcohol Polyethylene glycol 1-Propanol Polyethylene Glycols chemistry.chemical_compound Phenols Burns Chemical Phenol Medicine Animals Therapeutic Irrigation Histological examination Ethanol Chromatography business.industry Methanol Isopropyl alcohol Surgery chemistry Emergency Medicine Methylated spirit Water treatment business |
Zdroj: | Annals of emergency medicine. 21(11) |
ISSN: | 0196-0644 |
Popis: | To compare the effects of water rinse with those of isopropyl alcohol, polyethylene glycol with industrial methylated spirits, or ethanol on cutaneous phenol burns.Controlled trial with all animals receiving all treatments applied to different cutaneous phenol burn sites.Swine weighing 9 to 18 kg.In phase 1, each burn site was treated with water rinse for zero, one, or five minutes combined with either isopropyl alcohol, polyethylene glycol with industrial methylated spirits, ethanol, or no other treatment. Biopsies of treatment sites were done at 30 minutes and at 48 hours. In phase 2, a pilot study, the effect of isopropyl alcohol, polyethylene glycol with industrial methylated spirits, or water treatment on serum phenol levels was noted in animals with 5%, 10%, and 15% body surface area burns.In phase 1, on histological examination of biopsy specimens, significant differences in tissue damage occurred among the groups (P.05). Isopropyl alcohol and polyethylene glycol with industrial methylated spirits were the most efficacious treatments; the duration of water rinse had no significant effect. In phase 2, the systemic absorption of phenol may be greater with water treatment than with isopropyl alcohol treatment.Isopropyl alcohol and polyethylene glycol with industrial methylated spirits are equally effective in the amelioration of phenol burns of less than 5% total surface area. The wider availability of isopropyl alcohol makes it potentially the most useful treatment for these small burns. Further studies of its risks are needed. |
Databáze: | OpenAIRE |
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