Effect of apelin on glomerular hemodynamic function in the rat kidney
| Autor: | Annette Hus-Citharel, Catherine Llorens-Cortes, Laurence Bodineau, Nadine Bouby, Jean-Marie Gasc, Alain Frugière |
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| Přispěvatelé: | Neuropeptides centraux et régulations hydrique et cardiovasculaire, Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Collège de France ( CdF ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre de Recherche des Cordeliers ( CRC (UMR_S 872) ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Angiogénèse embryonnaire et pathologique, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Labex MemoLife, Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche des Cordeliers (CRC (UMR_S 872)), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre interdisciplinaire de recherche en biologie (CIRB), Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Llorens Cortes, Catherine, Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre interdisciplinaire de recherche en biologie (CIRB), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Labex MemoLife, Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 2008 |
| Předmět: |
Male
Afferent arterioles Vascular smooth muscle MESH : RNA Messenger MESH : Myocytes Smooth Muscle Kidney Glomerulus MESH : Receptors Cell Surface MESH : Arterioles vascular regulation Vasodilation glomerulus MESH: Rats Sprague-Dawley 030204 cardiovascular system & hematology Rats Sprague-Dawley MESH : Vasodilation 0302 clinical medicine MESH: Pregnancy Pregnancy MESH: Animals MESH : Female Receptor MESH: Receptors Cell Surface [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism 0303 health sciences MESH : Diuresis MESH : Hemodynamics MESH : Rats Angiotensin II MESH: Diuresis MESH: Myocytes Smooth Muscle [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism [ SDV.MHEP.EM ] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism Apelin Arterioles medicine.anatomical_structure MESH : Nitric Oxide Nephrology Intercellular Signaling Peptides and Proteins MESH: Vasoconstriction Female MESH: Angiotensin II MESH : Kidney Glomerulus MESH : Vasoconstriction MESH : Carrier Proteins medicine.medical_specialty MESH: Hemodynamics MESH: Rats MESH : Male Myocytes Smooth Muscle MESH: Carrier Proteins Receptors Cell Surface Nitric Oxide Microcirculation MESH : Angiotensin II MESH: Vasodilation 03 medical and health sciences MESH: Arterioles hemodynamic Internal medicine medicine Animals RNA Messenger 030304 developmental biology Apelin receptor MESH: RNA Messenger calcium business.industry Hemodynamics MESH: Kidney Glomerulus nephron MESH: Male MESH : Rats Sprague-Dawley Diuresis Rats MESH : Pregnancy Endocrinology Vasoconstriction MESH: Nitric Oxide MESH : Animals business Carrier Proteins MESH: Female |
| Zdroj: | Kidney International Kidney International, Nature Publishing Group, 2008, 74 (4), pp.486-94. 〈10.1038/ki.2008.199〉 Kidney International, Nature Publishing Group, 2008, 74 (4), pp.486-94. ⟨10.1038/ki.2008.199⟩ Kidney International, 2008, 74 (4), pp.486-94. ⟨10.1038/ki.2008.199⟩ |
| ISSN: | 1523-1755 0085-2538 |
| DOI: | 10.1038/ki.2008.199〉 |
| Popis: | International audience; Apelin is a vasoactive peptide identified as the endogenous ligand of an orphan G protein-coupled receptor called APJ. Apelin and its receptor have been found in the brain and the cardiovascular system. Here we show that the apelin receptor mRNA is highly expressed in the glomeruli while its level of expression is lower in all nephron segments including collecting ducts that express vasopressin V2 receptors. Intravenous injection of apelin 17 into lactating rats induced a significant diuresis. Apelin receptor mRNA was also found in endothelial and vascular smooth muscle cells of glomerular arterioles. Apelin administration caused vasorelaxation of angiotensin II-preconstricted efferent and afferent arterioles as shown by an increase in their diameter. Activation of endothelial apelin receptors caused release of nitric oxide which inhibited angiotensin II-induced rise in intracellular calcium. In addition, it appears that apelin had a direct receptor-mediated vasoconstrictive effect on vascular smooth muscle. These results show that apelin has complex effects on the pre- and post glomerular microvasculature regulating renal hemodynamics. Its role on tubular function (if any) remains to be determined. |
| Databáze: | OpenAIRE |
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