Comparison of two doses of aprotinin in patients receiving aspirin before coronary bypass surgery

Autor: Manuel Irarrazaval, Jessica Medel, Guillermo Lema, Renate Flaskamp, Sergio Moran, Ricardo Zalaquett, Bernardita Garayar
Rok vydání: 2000
Předmět:
Adult
Male
medicine.medical_specialty
medicine.medical_treatment
Premedication
Group ii
Blood Loss
Surgical
030204 cardiovascular system & hematology
Postoperative Hemorrhage
Hemostatics
03 medical and health sciences
0302 clinical medicine
Aprotinin
Blood loss
Double-Blind Method
medicine
Humans
Radiology
Nuclear Medicine and imaging
In patient
Blood Transfusion
Thoracotomy
Postoperative Period
Prospective Studies
Coronary Artery Bypass
Aged
Advanced and Specialized Nursing
Aspirin
Cardiopulmonary Bypass
Dose-Response Relationship
Drug
business.industry
General Medicine
Middle Aged
Surgery
Treatment Outcome
030228 respiratory system
Tolerability
Bypass surgery
Anesthesia
Drainage
Female
Safety
Cardiology and Cardiovascular Medicine
business
Safety Research
Platelet Aggregation Inhibitors
medicine.drug
Zdroj: Perfusion. 15(2)
ISSN: 0267-6591
Popis: This study was designed to evaluate efficacy and tolerability of two different doses of aprotinin in patients receiving aspirin before undergoing coronary artery bypass grafting. Forty-two patients were randomized to receive either placebo (group I), or aprotinin in doses of 4 000 000 KIU (group II) or 6 000 000 KIU (group III). Drug efficacy was determined by measuring postoperative blood loss and transfusion of blood products. Both doses were effective in reducing blood loss and transfusion requirements. Blood loss through thoracotomy drainage was 450 ± 224, 182 ± 144, 142 ± 98 ml, respectively, for control and treatment groups II and III ( p = 0.0001). The numbers of patients with blood transfusions were seven (50%), two (17%) and two (17%) for group I and treatment groups II and III, respectively ( p = 0.10). Tolerability was excellent and complications few and reversible. In conclusion, high and medium doses of aprotinin were well tolerated and reduced bleeding and transfusion requirements in patients submitted to coronary bypass surgery under the effects of aspirin.
Databáze: OpenAIRE
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