L1CAM expression in uterine carcinosarcoma is limited to the epithelial component and may be involved in epithelial-mesenchymal transition

Autor: Camilla Krakstad, Marco A. C. Versluis, Harry Hollema, Annechien Plat, G. H. de Bock, Tjalling Bosse, Xavier Matias-Guiu, J. Trovic, Hans W. Nijman, M. de Bruyn
Přispěvatelé: Targeted Gynaecologic Oncology (TARGON), Translational Immunology Groningen (TRIGR), Life Course Epidemiology (LCE), Damage and Repair in Cancer Development and Cancer Treatment (DARE), ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
PREDICTOR
L1
Malalties uterines
PROGRESSION
UP-REGULATION
Epithelium
Metastasis
0302 clinical medicine
Carcinosarcoma
Neural cell adhesion molecule L1
Keratin
ADHESION MOLECULE
chemistry.chemical_classification
Endometrial neoplasm
Epithelial–mesenchymal transition
EMT
General Medicine
Middle Aged
Epithelial-mesenchymal transition
Immunohistochemistry
TUMORS
CARCINOMAS
030220 oncology & carcinogenesis
Uterine Neoplasms
SURVIVAL
Female
Histology
Biology
Pathology and Forensic Medicine
03 medical and health sciences
Metàstasi
Biomarkers
Tumor
medicine
Humans
Molecular Biology
Aged
Retrospective Studies
Uterus diseases
Endometrial cancer
Mesenchymal stem cell
Cancer
Cell Biology
ENDOMETRIAL CANCER
medicine.disease
PATHOLOGY
030104 developmental biology
chemistry
L1CAM
Cancer research
Zdroj: Recercat. Dipósit de la Recerca de Catalunya
instname
Virchows Archiv, 473(5), 591-598
Repositorio Abierto de la UdL
Universitad de Lleida
Virchows Archiv : an International Journal of Pathology, 473(5), 591-598. SPRINGER
Dipòsit Digital de la UB
Universidad de Barcelona
ISSN: 0945-6317
Popis: Uterine carcinosarcoma (UCS) has been proposed as a model for epithelial–mesenchymal transition (EMT), a process characterized by a functional change facilitating migration and metastasis in many types of cancer. L1CAMis an adhesion molecule that has been involved in EMT as a marker for mesenchymal phenotype.We examined expression of L1CAM in UCS in a cohort of 90 cases from four different centers. Slides were immunohistochemically stained for L1CAMand scored in four categories (0%, < 10%, 10–50%, and > 50%). A score of more than 10% was considered positive for L1CAM. The median age at presentation was 68.6 years, and half of the patients (53.3%) presented with FIGO stage 1 disease. Membranous L1CAM expression was positive in the epithelial component in 65.4% of cases. Remarkably, expression was negative in the mesenchymal component. In cases where both components were intermingled, expression limited to the epithelial component was confirmed by a double stain for L1CAMand keratin. Expression of L1CAMdid not relate to overall or disease-free survival. Our findings suggest L1CAMis either not a marker for the mesenchymal phenotype in EMT, or UCS is not a good model for EMT.
Databáze: OpenAIRE
Externí odkaz: