L1CAM expression in uterine carcinosarcoma is limited to the epithelial component and may be involved in epithelial-mesenchymal transition
Autor: | Camilla Krakstad, Marco A. C. Versluis, Harry Hollema, Annechien Plat, G. H. de Bock, Tjalling Bosse, Xavier Matias-Guiu, J. Trovic, Hans W. Nijman, M. de Bruyn |
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Přispěvatelé: | Targeted Gynaecologic Oncology (TARGON), Translational Immunology Groningen (TRIGR), Life Course Epidemiology (LCE), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE) |
Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
PREDICTOR L1 Malalties uterines PROGRESSION UP-REGULATION Epithelium Metastasis 0302 clinical medicine Carcinosarcoma Neural cell adhesion molecule L1 Keratin ADHESION MOLECULE chemistry.chemical_classification Endometrial neoplasm Epithelial–mesenchymal transition EMT General Medicine Middle Aged Epithelial-mesenchymal transition Immunohistochemistry TUMORS CARCINOMAS 030220 oncology & carcinogenesis Uterine Neoplasms SURVIVAL Female Histology Biology Pathology and Forensic Medicine 03 medical and health sciences Metàstasi Biomarkers Tumor medicine Humans Molecular Biology Aged Retrospective Studies Uterus diseases Endometrial cancer Mesenchymal stem cell Cancer Cell Biology ENDOMETRIAL CANCER medicine.disease PATHOLOGY 030104 developmental biology chemistry L1CAM Cancer research |
Zdroj: | Recercat. Dipósit de la Recerca de Catalunya instname Virchows Archiv, 473(5), 591-598 Repositorio Abierto de la UdL Universitad de Lleida Virchows Archiv : an International Journal of Pathology, 473(5), 591-598. SPRINGER Dipòsit Digital de la UB Universidad de Barcelona |
ISSN: | 0945-6317 |
Popis: | Uterine carcinosarcoma (UCS) has been proposed as a model for epithelial–mesenchymal transition (EMT), a process characterized by a functional change facilitating migration and metastasis in many types of cancer. L1CAMis an adhesion molecule that has been involved in EMT as a marker for mesenchymal phenotype.We examined expression of L1CAM in UCS in a cohort of 90 cases from four different centers. Slides were immunohistochemically stained for L1CAMand scored in four categories (0%, < 10%, 10–50%, and > 50%). A score of more than 10% was considered positive for L1CAM. The median age at presentation was 68.6 years, and half of the patients (53.3%) presented with FIGO stage 1 disease. Membranous L1CAM expression was positive in the epithelial component in 65.4% of cases. Remarkably, expression was negative in the mesenchymal component. In cases where both components were intermingled, expression limited to the epithelial component was confirmed by a double stain for L1CAMand keratin. Expression of L1CAMdid not relate to overall or disease-free survival. Our findings suggest L1CAMis either not a marker for the mesenchymal phenotype in EMT, or UCS is not a good model for EMT. |
Databáze: | OpenAIRE |
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