Essential Thrombocythemia Due to Janus Kinase 2 Mutation Unmasked After Splenectomy
| Autor: | Rahul Gupta, Jyoti Gupta, Archana Khanduri, Houssem Ammar |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Splenectomy thrombocytosis Spleen Gastroenterology jak 2 mutation splenectomy Myeloproliferative Disorders Internal medicine medicine Platelet Janus kinase 2 essential thrombocythemia biology Thrombocytosis business.industry Essential thrombocythemia General Engineering splenic trauma Hematology Iron deficiency medicine.disease myeloproliferative disorders medicine.anatomical_structure General Surgery Emergency Medicine biology.protein business |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| DOI: | 10.7759/cureus.15357 |
| Popis: | Reactive thrombocytosis after splenectomy is common and often self-limiting. However, thrombocytosis can be multifactorial, especially extreme thrombocytosis (platelet count > 100 x 104/cubic mm). It can lead to thrombotic or hemorrhagic complications. Hence, in patients with rising platelet count after splenectomy, detailed evaluation may be required to rule out other causes of thrombocytosis, such as infection, iron deficiency, and myeloproliferative disorders. Timely treatment of patients with thrombocytosis can prevent the development of life-threatening complications. The index case highlights the importance of regular follow-up of the patients after splenectomy to detect thrombocytosis and suspect other causes if the spleen was diseased or the platelet count fails to resolve spontaneously. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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