Elution and mechanical properties of antifungal bone cement
| Autor: | Benjamin G. Goss, Ross Crawford, Cameron Lutton, Majid Jabur, Greg Gillett, Patrick C. Weinrauch |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Cement
Chromatography Antifungal Agents Prosthesis-Related Infections business.industry Elution medicine.drug_class Spectrum Analysis Antibiotics Bone Cements Periprosthetic Bone cement Microbiology Anti-Bacterial Agents Compressive strength Mycoses Amphotericin B Tobramycin medicine Humans Orthopedics and Sports Medicine business medicine.drug |
| Zdroj: | The Journal of arthroplasty. 22(6) |
| ISSN: | 0883-5403 |
| Popis: | The effect of the incorporation of amphotericin B into bone cement was examined; as literature suggests, this may be a feasible method for the treatment of periprosthetic fungal infections. Addition of antifungal increased the compressive strength of the bone cement--a statistically significant amount from 107 +/- 2.3 to 121 +/- 1.5 MPa. Elution of tobramycin and amphotericin B was quantified using ultraviolet-visible spectroscopy. Spectroscopy showed that 18% of the antibiotic was released during the first week, with most released in the first 24 hours. The elution of antifungal, however, was unable to be detected after 1 week, with less than 0.03% released. Amphotericin B does not weaken bone cement. Its inability to be delivered at a clinically significant dose gives no clear indication for its incorporation into cement. |
| Databáze: | OpenAIRE |
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