Differential Involvement of Opioid Receptors in Intrathecal Butorphanol-Induced Analgesia: Compared to Morphine
| Autor: | B.K. Tsang, Wichai Wongchanapai, Z. He, Ing Kang Ho |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
Butorphanol medicine.drug_class Narcotic Antagonists Clinical Biochemistry Pharmacology Toxicology Biochemistry Rats Sprague-Dawley Behavioral Neuroscience Naltrindole Opioid receptor medicine Animals Receptor Injections Spinal Biological Psychiatry Pain Measurement Dose-Response Relationship Drug Morphine Chemistry Naltrexone Rats Analgesics Opioid Nociception Mechanism of action Opioid Receptors Opioid medicine.symptom medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 59:723-727 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/s0091-3057(97)00558-3 |
| Popis: | The present experiments were performed to investigate the differential involvement of the opioid receptor subtypes in the antinociception of intrathecal (IT) butorphanol compared to IT morphine. A single dose (26 nmol) of IT nor-binaltorphimine (nor-BNI), beta-funaltrexamine (beta-FNA), and naltrindole (NTI) demonstrated a significant attenuation in the overall antinociception of IT butorphanol (52 nmol) or IT morphine (26 nmol). However, IT butorphanol elicits thermal antinociceptive effect through kappadeltaor = mu, whereas morphine acts on mudeltakappa. These results indicate that the antinociceptive effect of both IT butorphanol and IT morphine are mediated through mu, delta, and kappa opioid receptors in different relative orders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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