An occurrence of neurotoxic shellfish poisoning by consumption of gastropods contaminated with brevetoxins
| Autor: | Jennifer T. Jackson, Ann Abraham, Kathleen R. El Said, William Odom, Dean W. Bodager, Leanne J. Flewelling, Stephen P. Geiger, April A. Granholm |
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| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
animal structures Gastropoda Neurotoxic shellfish poisoning Macrocallista nimbosa Zoology Enzyme-Linked Immunosorbent Assay Toxicology 01 natural sciences 03 medical and health sciences Brevetoxin Tandem Mass Spectrometry Animals Humans Shellfish Poisoning Shellfish 0303 health sciences biology 010604 marine biology & hydrobiology Cinctura hunteria Oxocins 030302 biochemistry & molecular biology Strombus alatus biology.organism_classification Bivalvia Dinoflagellida Florida Biological Assay Marine Toxins Karenia brevis Chromatography Liquid Triplofusus giganteus |
| Zdroj: | Toxicon. 191:9-17 |
| ISSN: | 0041-0101 |
| Popis: | Brevetoxins were confirmed in urine specimens from patients diagnosed with neurotoxic shellfish poisoning (NSP) after consumption of gastropods that were recreationally harvested from an area previously affected by a Karenia brevis bloom. Several species of gastropods (Triplofusus giganteus, Sinistrofulgur sinistrum, Cinctura hunteria, Strombus alatus, Fulguropsis spirata) and one clam (Macrocallista nimbosa) from the NSP implicated gastropod collection area (Jewfish Key, Sarasota Bay, Florida) were examined for brevetoxins using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and enzyme-linked immunosorbent assay (ELISA). All gastropods and the clam were contaminated with brevetoxins. Composite B-type toxin concentrations in gastropods ranged from 1.1 to 198 μg BTX-3 equiv./g by ELISA, levels likely capable of causing NSP in consumers. Several brevetoxin metabolites previously characterized in molluscan shellfish were identified in these gastropods. Brevetoxin analog profiles by ELISA were similar in the gastropod species examined. This work documents the occurrence of NSP through consumption of a type of seafood not typically monitored in Florida to protect human health, demonstrating the need to better assess and communicate the risk of NSP to gastropod harvesters in Karenia brevis endemic areas. |
| Databáze: | OpenAIRE |
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