Epidemiology of human influenza A(H7N9) infection in Hong Kong
| Autor: | Shuk-Kwan Chuang, May-kei To, Oi-shan Leung, Yiu-hong Leung, Tsz-sum Lam, Shui-wah Yau |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Epidemiology lcsh:QR1-502 Avian influenza medicine.disease_cause Influenza A Virus H7N9 Subtype Poultry lcsh:Microbiology Disease Outbreaks chemistry.chemical_compound 0302 clinical medicine Zoonoses Influenza A virus Immunology and Allergy 030212 general & internal medicine Child Aged 80 and over Reverse Transcriptase Polymerase Chain Reaction General Medicine Middle Aged Virus Shedding Infectious Diseases Child Preschool Human mortality from H5N1 Hong Kong Female Seasons Adult Microbiology (medical) medicine.medical_specialty Oseltamivir Adolescent Influenza A virus H7N9 subtype 030106 microbiology H5N1 genetic structure Antiviral Agents Incubation period 03 medical and health sciences Young Adult Internal medicine Immunology and Microbiology(all) Influenza Human medicine Animals Humans Viral shedding Aged General Immunology and Microbiology business.industry Infant Virology Influenza A virus subtype H5N1 chemistry Influenza in Birds business Case series |
| Zdroj: | Journal of Microbiology, Immunology and Infection, Vol 50, Iss 2, Pp 183-188 (2017) |
| ISSN: | 1684-1182 |
| Popis: | Background/Purpose We conducted a case series study to review the epidemiology of human influenza A(H7N9) infection reported in Hong Kong. Methods We reviewed case records of confirmed human cases of influenza A(H7N9) infection reported in Hong Kong in the 2013–2014 winter season. We compared the median viral shedding duration and interval from illness onset to initiation of oseltamivir treatment between severe and mild cases. We estimated the incubation period of influenza A(H7N9) virus from cases with a single known date of poultry exposure. Results A total of 10 cases were reported and all were imported infection from Mainland China. Four patients died and the cause of death was related to influenza A(H7N9) infection in two patients. The median interval from illness onset to initiation of oseltamivir treatment for the severe cases (4.5 days) was significantly longer than the mild cases (2 days; p = 0.025). Severe cases had a significantly longer viral shedding duration than mild cases ( p = 0.028). The median incubation period for cases with a single known exposure date was 4 days. Nasopharyngeal aspirate taken from the 88 close contacts of the 10 patients all tested negative for influenza A virus using reverse transcription polymerase chain reaction. Conclusion Delayed administration of antiviral treatment may be associated with a more severe illness for influenza A(H7N9) infection. Despite our aggressive contact tracing policy with laboratory testing of all close contacts, no secondary case was identified which implied that the potential of human-to-human transmission of the circulating influenza A(H7N9) virus remains low. |
| Databáze: | OpenAIRE |
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