Autoantibodies against glucose-regulated protein 78 as serological biomarkers in metastatic and recurrent hepatocellular carcinoma
| Autor: | Qing Zhu, Yiping Dong, Congya Zhou, Xia Ying, Mengjiao Cai, Chenchen He, Xin Sui, Wenli Gou, Chengxian Ma, Suxia Han, Xiao Sun, Yuanyuan Zhang, Clifford W. Mason |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Cirrhosis Carcinoma Hepatocellular autoantibodies Enzyme-Linked Immunosorbent Assay Gastroenterology Metastasis 03 medical and health sciences 0302 clinical medicine heptocellular carcinoma (HCC) proteomics Obstetrics and gynaecology Internal medicine Cell Line Tumor medicine Carcinoma Biomarkers Tumor Humans Neoplasm Metastasis Fluorescent Antibody Technique Indirect Endoplasmic Reticulum Chaperone BiP Heat-Shock Proteins business.industry Liver Neoplasms Autoantibody Hep G2 Cells medicine.disease HCT116 Cells Recurrent Hepatocellular Carcinoma digestive system diseases 030104 developmental biology Oncology 030220 oncology & carcinogenesis Case-Control Studies tumor associated antigens (TAA) MCF-7 Cells Biomarker (medicine) Immunohistochemistry biomarker business Research Paper HeLa Cells |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Xia Ying 1, 2 , Su-xia Han 3 , Chen-chen He 3 , Cong-ya Zhou 1 , Yi-ping Dong 3 , Meng-jiao Cai 1 , Xin Sui 3 , Cheng-xian Ma 1 , Xiao Sun 3 , Yuan-yuan Zhang 1 , Wen-li Gou 4 , Clifford Mason 5 , Qing Zhu 1 1 Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi’an, Shannxi, P.R. China 2 Department of Gynecological Oncology, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P.R. China 3 Department of Oncology, The First Affiliated Hospital of Xi’an Jiaotong University Medical College, Xi’an, Shannxi, P.R. China 4 Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi’an Jiaotong University Medical College, Xi’an, Shannxi, P.R. China 5 Department of Obstetrics and Gynecology, University of Kansas School of Medicine, Kansas City, Kansas, USA Correspondence to: Qing Zhu, email: newzhuqing1972@yahoo.com Keywords: heptocellular carcinoma (HCC), tumor associated antigens (TAA), proteomics, autoantibodies, biomarker Received: June 03, 2016 Accepted: December 05, 2016 Published: February 08, 2017 ABSTRACT Purpose: To identify Heptocellular carcinoma (HCC) associated antigens by proteomics, and validate whether autoantibodies against tumor-associated antigens (TAAs) could be used for diagnosis and conditional monitoring. Results: The 78 kDa glucose regulated protein (GRP78) was selected as a candidate TAA. The titers of autoantibodies against 78 kDa glucose regulated protein (GRP78) from patients with HCC, liver cirrhosis (LC), and chronic hepatitis (CH) were significantly higher than that from normal controls ( P |
| Databáze: | OpenAIRE |
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