The translocator maintenance protein Tam41 is required for mitochondrial cardiolipin biosynthesis
| Autor: | Xue Li Guan, Philip Heacock, William Dowhan, Stephan Kutik, Peter Rehling, Michael Rissler, Natalia Gebert, Nils Wiedemann, Bernard Guiard, Nikolaus Pfanner, Markus R. Wenk, Guanghou Shui |
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| Rok vydání: | 2008 |
| Předmět: |
Saccharomyces cerevisiae Proteins
Cardiolipins Translocase of the outer membrane TIM/TOM complex Saccharomyces cerevisiae Biology Mitochondrial Membrane Transport Proteins Mitochondrial Proteins 03 medical and health sciences Mitochondrial membrane transport protein chemistry.chemical_compound 0302 clinical medicine Report Mitochondrial Precursor Protein Import Complex Proteins Cardiolipin Inner mitochondrial membrane Research Articles 030304 developmental biology Membrane Potential Mitochondrial 0303 health sciences Membrane Transport Proteins Cell Biology Mitochondrial carrier Cell biology Mitochondria chemistry Biochemistry Translocase of the inner membrane biology.protein ATP–ADP translocase 030217 neurology & neurosurgery |
| Zdroj: | The Journal of Cell Biology |
| ISSN: | 1540-8140 |
| Popis: | The mitochondrial inner membrane contains different translocator systems for the import of presequence-carrying proteins and carrier proteins. The translocator assembly and maintenance protein 41 (Tam41/mitochondrial matrix protein 37) was identified as a new member of the mitochondrial protein translocator systems by its role in maintaining the integrity and activity of the presequence translocase of the inner membrane (TIM23 complex). Here we demonstrate that the assembly of proteins imported by the carrier translocase, TIM22 complex, is even more strongly affected by the lack of Tam41. Moreover, respiratory chain supercomplexes and the inner membrane potential are impaired by lack of Tam41. The phenotype of Tam41-deficient mitochondria thus resembles that of mitochondria lacking cardiolipin. Indeed, we found that Tam41 is required for the biosynthesis of the dimeric phospholipid cardiolipin. The pleiotropic effects of the translocator maintenance protein on preprotein import and respiratory chain can be attributed to its role in biosynthesis of mitochondrial cardiolipin. |
| Databáze: | OpenAIRE |
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