Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene
| Autor: | Jeffrey I. Gordon, Masayuki Masu, Stephanie L. Dickinson, Roderick T. Bronson, Amin Fazeli, Robert Tighe, Michelle L. Hermiston, Robert G. Steen, Clayton G. Small, Helen Rayburn, Robert A. Weinberg, Kazuko Keino-Masu, Marc Tessier-Lavigne, Esther T. Stoeckli, Jonathan W. Simons |
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| Rok vydání: | 1997 |
| Předmět: |
Deleted in Colorectal Cancer
Tumor suppressor gene Receptors Cell Surface Dependence receptor Biology medicine.disease_cause UNC5C Mice Netrin Receptor DCC Intestinal Neoplasms Netrin medicine Animals Humans Nerve Growth Factors Intestinal Mucosa Multidisciplinary Brain Neoplasms Chimera Tumor Suppressor Proteins fungi Brain Chromosome Mapping Intestinal Polyps Gene targeting Netrin-1 DCC Receptor Axons Mice Inbred C57BL Genes DCC Phenotype Spinal Cord nervous system Mutagenesis Gene Targeting Cancer research Colorectal Neoplasms Carcinogenesis Cell Adhesion Molecules Cell Division |
| Zdroj: | Nature. 386:796-804 |
| ISSN: | 1476-4687 0028-0836 |
| Popis: | The DCC (Deleted in colorectal cancer) gene was first identified as a candidate for a tumour-suppressor gene on human chromosome 18q. More recently, in vitro studies in rodents have provided evidence that DCC might function as a receptor for the axonal chemoattractant netrin-1. Inactivation of the murine Dcc gene caused defects in axonal projections that are similar to those observed in netrin-1-deficient mice but did not affect growth, differentiation, morphogenesis or tumorigenesis in mouse intestine. These observations fail to support a tumour-suppressor function for Dcc, but are consistent with the hypothesis that DCC is a component of a receptor for netrin-1. |
| Databáze: | OpenAIRE |
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