Region-Specific Enhancement of c-fos Expression by Combined Treatment With NMDA Receptor Agonists and Antagonists With Antidepressant Potential

Autor:	Andrei-Nicolae Vasilescu, Natascha Pfeiffer, Federica Terraneo, Marco Andrea Riva, Undine E Lang, Dragos Inta, Peter Gass
Rok vydání:	2022
Předmět:	Pharmacology MK-801 D-Cycloserine NMDA receptors Rapastinel antidepressant drug Receptors N-Methyl-D-Aspartate Antidepressive Agents Psychiatry and Mental health Settore BIO/14 - Farmacologia Pharmacology (medical) Dizocilpine Maleate Excitatory Amino Acid Antagonists Proto-Oncogene Proteins c-fos
Zdroj:	International Journal of Neuropsychopharmacology. 25:946-950
ISSN:	1469-5111 1461-1457
DOI:	10.1093/ijnp/pyac051
Popis:	Summary Rapastinel, formerly Glyx-13, is a novel positive allosteric modulator of the N-methyl-D-aspartate-receptor (NMDAR) that counteracts psychotomimetic actions of NMDAR antagonists. We set out to evaluate the effect of rapastinel alone or in combination with the global and GluN2B subunit–specific NMDAR antagonists MK-801 and Ro25-6981, respectively, on neuronal activation in relevant regions using c-fos brain mapping. Whereas rapastinel alone did not trigger significant c-fos expression beyond the prelimbic cortex, it strongly increased the c-fos expression induced by MK-801 in hippocampal, cingulate, and retrosplenial areas. Similar results were obtained when rapastinel was replaced by D-cycloserine. Our results reveal new interactions at network level between NMDAR modulators with possible implications regarding their therapeutic effects.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f59ffdaff55a79c3a82f81a3809172c https://doi.org/10.1093/ijnp/pyac051 Zobrazit plný text záznamu