| Popis: |
When it was demonstrated that sulfonamide activity can be explained, at least in part, by competition with p‐aminobenzoic acid for some enzyme‐controlled metabolic system, increased interest was displayed in the ability of drugs to compete with essential metabolites. Although this conception of drug activity started with anti‐infective agents, it soon spread to the vitamin field where it was shown that the administration of many analogues of vitamins can produce vitamin deficiencies. A probable explanation of salicylate poisoning in terms of vitamin K competition is also offered. This concept of drug action, reviewed here, offers a new point of departure in chemotherapy and a means of explaining the mechanism of action of certain drugs. |
