Waist Circumference as a Predictor of Adiponectin Levels in Peritoneal Dialysis Patients: A 12-Month Follow-up Study
| Autor: | Maria Ayako Kamimura, Lilian Cuppari, Silvia Regina Manfredi, Maria Eugênia Fernandes Canziani, Ana Paula Bazanelli |
|---|---|
| Přispěvatelé: | Universidade Federal de São Paulo (UNIFESP) |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Nephrology medicine.medical_specialty Time Factors Waist medicine.medical_treatment Abdominal Fat Adipokine abdominal obesity Peritoneal dialysis Adipokines Internal medicine parasitic diseases medicine Humans Prospective Studies Renal Insufficiency Chronic Prospective cohort study Abdominal obesity Adiposity Aged Adiponectin business.industry Original Articles General Medicine Middle Aged waist circumference Circumference Surgery Female Waist Circumference medicine.symptom business Peritoneal Dialysis Brazil Follow-Up Studies |
| Zdroj: | Repositório Institucional da UNIFESP Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| ISSN: | 1718-4304 0896-8608 |
| Popis: | Clinical Evidence Council (CEC) Grant (Baxter Healthcare Corporation-Renal) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Oswaldo Ramos Foundation Objectives: This prospective study, conducted at the dialysis unit of the Nephrology Division, Federal University of São Paulo-Oswaldo Ramos Foundation, Brazil, aimed to evaluate whether waist circumference (WC) can predict adiponectin levels in patients undergoing peritoneal dialysis (PD).Methods: Among 115 patients on PD at a single dialysis center who were evaluated at 6 and 12 months, 57% were men, 31% had diabetes, mean age was 52.8 +/- 16.1 years, body mass index was 25 +/- 4.3 kg/m(2), and dialysis vintage was 13 months (range: 5 - 33 months). We measured WC at the umbilicus level. Adiponectin was determined by an enzyme-linked immunosorbent assay.Results: At baseline, WC was inversely associated with adiponectin (r = -0.48, p < 0.01). After adjustment for sex, age, diabetes, peritoneal clearance, and residual renal function, WC was an independent determinant of serum adiponectin (beta = -0.52; 95% confidence interval: -0.73 to -0.31; p < 0.001). in the prospective analysis, after adjustment for confounders, changes in WC predicted changes in adiponectin. for each unit increase in WC, adiponectin declined by 0.39 mg/L (p < 0.001).Conclusions: This study demonstrates that WC is associated with adiponectin and, more importantly, that this simple marker of central adiposity was able to predict changes in adiponectin levels over time. Perit Dial Int 2013; 33(2):182-188 www.PDIConnect.com epub ahead of print: 01 Sep 2012 doi:10.3747/pdi.2011.00129 Universidade Federal de São Paulo, Nutr Program, BR-04039000 São Paulo, Brazil Universidade Federal de São Paulo, Div Nephrol, BR-04039000 São Paulo, Brazil Universidade Federal de São Paulo, Nutr Program, BR-04039000 São Paulo, Brazil Universidade Federal de São Paulo, Div Nephrol, BR-04039000 São Paulo, Brazil Web of Science |
| Databáze: | OpenAIRE |
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