A hospital-based case control study of aplastic anemia in Shanghai, China
| Autor: | A. Robert Schnatter, G. Bruce Copley, Sherilyn A. Gross, Xiaoqin Wang, John Ryder, Thomas W. Armstrong, Richard D. Irons |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty China Multivariate analysis Adolescent Anemia Toxicology Young Adult Risk Factors Statistical significance Internal medicine Medicine Humans Young adult Aplastic anemia Aged Hepatitis Aged 80 and over business.industry Confounding Case-control study Anemia Aplastic Benzene General Medicine Middle Aged medicine.disease Case-Control Studies Immunology Multivariate Analysis Female business |
| Zdroj: | Chemico-biological interactions. 184(1-2) |
| ISSN: | 1872-7786 |
| Popis: | We report results of a hospital-based case control study of 137 consecutive patients diagnosed with aplastic anemia (AA) in participating hospitals over a 4-year period. Diagnoses were made by a single laboratory, subjects were age- and gender-matched to two controls and interviewed concerning previous disease, work histories and exposures to potential etiologic agents. Analysis was conducted on two distinct subgroups: severe aplastic anemia (SAA) and moderate aplastic anemia (MAA). In univariate regression models, the strongest associations were observed for exposure to benzene and SAA (OR=3.12, 95% CI=1.12-8.65) and life on a farm and MAA (OR=3.08, 95% CI=1.44-6.56). Benzene exposure did not show a strong dose-response relationship with either subtype. When accounting for all of the potential confounders we considered in conditional regression models, the previous relationships persisted. Other explanatory variables included hair-dye use for MAA and farm exposures, such as livestock for SAA, although most of these additional variables fell just short of statistical significance. Adjusted R-squared values were only 10% for each subtype, leaving 90% of AA occurrence unexplained. Our results suggest that: (a) benzene exposure is more strongly related to SAA than MAA, (b) farm and livestock exposures are related to both forms of AA, confirming some previous results, and (c) a large percentage of AA remains unexplained, which may indicate that individual susceptibility has a major influence on AA occurrence. |
| Databáze: | OpenAIRE |
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