Altered polysomnographic profile in juvenile myoclonic epilepsy
| Autor: | Pramod Krishnan, Sanjib Sinha, Arun B Taly, Parthasarathy Satishchandra, Shivaji Rao, Chaitra T. Ramachandraiah |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Sleep Wake Disorders Adolescent Polysomnography Electroencephalography Non-rapid eye movement sleep Epilepsy Young Adult medicine Humans Prospective Studies Valproic Acid medicine.diagnostic_test Myoclonic Epilepsy Juvenile medicine.disease Sleep in non-human animals Brain Waves Cross-Sectional Studies Neurology Anesthesia Case-Control Studies Cohort Anticonvulsants Female Neurology (clinical) Sleep onset latency Juvenile myoclonic epilepsy Psychology medicine.drug |
| Zdroj: | Epilepsy research. 108(3) |
| ISSN: | 1872-6844 |
| Popis: | Summary Purpose To study the spectra of sleep profile using PSG in a cohort of patients with JME attending a University hospital. Methodology This prospective cross-sectional case–control study involved 25 patients of JME (age: 22.0±6.3 years; M:F=13:12) on valproic acid (VPA) and 25 matched healthy controls (age: 23.2±3.04 years; M:F=16:9) were recruited. All patients underwent clinical assessment, electroencephalogram (EEG), and evaluation with sleep questionnaire and PSG. Results PSG analysis revealed significant alterations in sleep architecture in the JME group in the form of reduced mean sleep efficiency ( p = p =0.001), increased mean sleep onset latency ( p =0.04) and number of patients with increased sleep latency ( p =0.023), reduced mean N2 sleep percentage ( p =0.005) and reduced mean total NREM (non-rapid eye movement) sleep ( p =0.001) and increased mean wake percentage ( p =0.001). The frequency of arousals, involuntary limb movements, and event related arousals in the JME groups was not different from the controls. Patients >20 years had reduced total sleep time compared to those p =0.012). Patients with seizures for >5 years had reduced NREM sleep percentage ( p =0.042) and those on VPA therapy >1 year had a longer stage 2 ( p =0.03) and N3 latency ( p =0.03). Patients on ≤600mg/day of VPA had a higher prevalence of isolated limb movements ( p =0.01). Conclusions PSG revealed significant alterations in sleep architecture in JME despite adequate seizure control. There was variable degree of PSG–phenotypic correlation. |
| Databáze: | OpenAIRE |
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