Investigation of Physiological Role of Mitochondrial KATP Channel’s on Penicillin G Induced Experimental Epilepsy Model in Rats

Autor:	Serif Demir, Ömer Bozdoğan, Hayriye Soytürk
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Penicillin Epilepsy Electrophysiology KATP Bepridil Mito KATP Channel Epilepsy Experimental epilepsy Chemistry Katp channels Health Care Sciences and Services medicine Pharmacology Sağlık Bilimleri ve Hizmetleri medicine.drug
Zdroj:	Volume: 16, Issue: 1 19-29 Medical Sciences
ISSN:	1308-7312
Popis:	Epilepsy is one of the neurological diseases that is commonly seen in the world. It is characterized by excessive activation of neurons that can not be controlled by the central nervous system. ATP dependent potassium (KATP) channel modulation is related with the epilepsy. This study is intended to research the physiological role of mitochondrial KATP channels in epilepsy in electrophysiological perspective. And bepridil has been used for this purpose. Wistar albino rats have been used. Animals have been divided into three main groups; Control, bepridil applied groups in pre-seizure, and during seizure. As a result, bepridil once applied prior to seizure in 0.1 and 1mg/kg doses increased the latency period of the seizure. Bepridil showed anticonvulsant effect at doses of 0.1 and 1 mg/kg before and during seizure groups. Closure of sarcoplasmic channels and opening of mitochondrial channels may be important to decrease the convultion occurred during epilepy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f51e2e96bb7ed3d628df37b6015d669 https://dergipark.org.tr/tr/pub/nwsamed/issue/59823/788026 Zobrazit plný text záznamu