Impact of age and comorbidity on survival among patients with oral cavity squamous cell carcinoma
| Autor: | Theodoros N. Teknos, Amit Agrawal, Ricardo L. Carrau, Bhavna Kumar, Krupal B. Patel, James W. Rocco, Matthew O. Old, Enver Ozer, Songzhu Zhao, Daniel Martin, Stephen Y. Kang, Guy Brock, David E. Schuller |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Prognostic variable Comorbidity Article 03 medical and health sciences 0302 clinical medicine Internal medicine Adjuvant therapy Medicine Humans 030212 general & internal medicine Oral Cavity Squamous Cell Carcinoma Cancer staging Neoplasm Staging Proportional Hazards Models Retrospective Studies business.industry Squamous Cell Carcinoma of Head and Neck Head and neck cancer Cancer Retrospective cohort study medicine.disease Prognosis Otorhinolaryngology Head and Neck Neoplasms 030220 oncology & carcinogenesis Carcinoma Squamous Cell business |
| Zdroj: | Head Neck |
| ISSN: | 1097-0347 |
| Popis: | Objective To identify predictors of overall survival (OS) and to stratify patients according to significant prognostic variables. Methods A retrospective study of 274 consecutive patients with primary Oral Cavity Squamous Cell Carcinoma. Kaplan-Meier, Cox proportional hazard models, and recursive partitioning analysis (RPA) were used for analysis of OS. These results were further validated using National Cancer Database cohort of 21 895 patients. Results Median OS was 3.65 years. T-classification and N-classification, alcoholic beverages/week, age, and adjuvant treatment were significant predictors of OS. RPA identified high-risk subpopulations: N0-1 patients with CCI ≥ 4.5 and N2-3 patients ordered by those not receiving adjuvant treatment, those with T3-4 disease despite adjuvant therapy, and those having T1-2 disease with adjuvant therapy. Conclusions This study utilized significant prognostic indicators and RPA to highlight the importance of age, N-classification, T-classification, comorbidity, and adjuvant therapy in conjunction with American Joint Committee on Cancer staging to improve preoperative counseling. |
| Databáze: | OpenAIRE |
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