Effects of intracerebroventricular administration of 5-HT receptor agonists on the maternal aggression of rats
| Autor: | Aldo Bolten Lucion, R. M. M. de Almeida |
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| Rok vydání: | 1994 |
| Předmět: |
Agonist
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Piperazine hydrochloride Pharmacology Piperazines Internal medicine medicine Animals Rats Wistar Receptor Maternal Behavior Saline 5-HT receptor Injections Intraventricular 8-Hydroxy-2-(di-n-propylamino)tetralin Analysis of Variance business.industry musculoskeletal neural and ocular physiology Significant difference Amphetamines Rats Serotonin Receptor Agonists Aggression Endocrinology nervous system Maternal aggression Female Serotonin business |
| Zdroj: | European journal of pharmacology. 264(3) |
| ISSN: | 0014-2999 |
| Popis: | This study attempted to analyze the effects of 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin), TFMPP (1-(3-trifluoromethyl-phenyl)piperazine hydrochloride), and DOI (1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane) on maternal aggressive behavior. Female Wistar rats were divided into 4 groups of 12 animals each. They received an intracerebroventricular (i.c.v.) injection of: (1) saline, (2) 8-OH-DPAT (20 micrograms/rat), (3) TFMPP (100 micrograms/rat), and (4) DOI (100 micrograms/rat). 5-HT1A (8-OH-DPAT) and 5-HT2 (DOI) receptor agonists decreased the frequency of attack 15 but not 55 min after i.c.v. injection. The 5-HT1B/D receptor agonist (TFMPP), in the dose studied, showed no significant difference as compared to saline. Pup care and non-aggressive social interaction with the intruder were not affected by any drug. These data suggest that 5-HT1A and 5-HT2 receptor agonists can specifically inhibit maternal aggression without affecting maternal care; however, this effect is of short duration. |
| Databáze: | OpenAIRE |
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