Effect of untreated pharmaceutical plant effluent on cardiac Na+-K+- ATPase and Ca2+-Mg2+-ATPase activities in mice (Mus Musculus)
| Autor: | O.O. Akinbobola, S.A. Busari, T.F. Olafimihan, A.O. Abdulkareem, Lawrence A. Olatunji |
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| Rok vydání: | 2019 |
| Předmět: |
Ca2+-Mg2+-ATPase
Health Toxicology and Mutagenesis Male mice 010501 environmental sciences Toxicology complex mixtures 01 natural sciences Article Na+-K+-ATPase 03 medical and health sciences 0302 clinical medicine Animal science lcsh:RA1190-1270 Mus musculus Na+/K+-ATPase Water pollution Effluent lcsh:Toxicology. Poisons 0105 earth and related environmental sciences Cardiotoxicity Chemistry Distilled water Aquatic environment Cardiac 030217 neurology & neurosurgery Ca2 mg2 atpase |
| Zdroj: | Toxicology Reports, Vol 6, Iss, Pp 439-443 (2019) Toxicology Reports |
| ISSN: | 2214-7500 |
| DOI: | 10.1016/j.toxrep.2019.05.002 |
| Popis: | Cardiovascular diseases are major causes of non-communicable diseases (NCDs)-related throughout the world. Water pollution has been linked with the high global NCD burden but no report exists on the cardiotoxicity of untreated or poorly treated pharmaceutical effluent, despite its indiscriminate discharge into the aquatic environment in Nigeria, as in many other locations of the world. Thus, this study investigated the cardiotoxic effect of oral exposure to pharmaceutical effluent in mice. Thirty (30) male mice (Mus musculus) were randomly divided into 6 groups. Group A (control) received 0.2 ml distilled water, while groups B-F were treated with 0.2 ml 2.5%, 5.0%, 10.0%, 20.0% and 40% concentrations (v/v, effluent/distilled water) of the effluent respectively, for 28 days. Significant reductions (p |
| Databáze: | OpenAIRE |
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