Large retroperitoneal lymphadenopathy and increased risk of venous thromboembolism in patients receiving first‐line chemotherapy for metastatic germ cell tumors: A study by the global germ cell cancer group (G3)

Autor: Xavier Garcia del Muro, Alexey Tryakin, Anis A. Hamid, Daniel Castellano, Philippe L. Bedard, Enrique Gonzalez-Billalabeitia, Anna Patrikidou, Tina Cheng, Giovannella Palmieri, Carsten Bokemeyer, Robert Kitson, Christian D. Fankhauser, Christoph Seidel, Edmond M. Kwan, Margarida Brito, Margaret Ottaviano, Aude Flechon, Thomas Hermanns, Daniel Y.C. Heng, Eitan Amir, Jose Manuel Ruiz-Morales, Alison Reid, Alexey Rumyantsev, Ben Tran
Přispěvatelé: University of Zurich, Tran, Ben
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Cancer Research
pulmonary embolism
medicine.medical_treatment
Gastroenterology
0302 clinical medicine
Catheters
Indwelling
Risk Factors
Antineoplastic Combined Chemotherapy Protocols
1306 Cancer Research
Child
Original Research
education.field_of_study
Middle Aged
Neoplasms
Germ Cell and Embryonal
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Pulmonary embolism
testicular cancer
Oncology
030220 oncology & carcinogenesis
Lymphatic Metastasis
2730 Oncology
Vascular Access Devices
Adult
medicine.medical_specialty
Adolescent
Retroperitoneal Lymph Node
Population
venous thromboembolism
610 Medicine & health
Risk Assessment
lcsh:RC254-282
deep vein thrombosis
03 medical and health sciences
Young Adult
vascular access device
Internal medicine
medicine
2741 Radiology
Nuclear Medicine and Imaging
Humans
Radiology
Nuclear Medicine and imaging
Retroperitoneal Neoplasms
Retroperitoneal Space
cardiovascular diseases
education
Testicular cancer
Aged
Retrospective Studies
Chemotherapy
business.industry
Clinical Cancer Research
germ cell tumor
medicine.disease
10062 Urological Clinic
030104 developmental biology
Germ cell tumors
Metastatic Germ Cell Tumor
Lymph Nodes
Cisplatin
business
Venous thromboembolism
Zdroj: Cancer Medicine, Vol 9, Iss 1, Pp 116-124 (2020)
Cancer Medicine
ISSN: 2045-7634
Popis: Background Metastatic germ cell tumor (mGCT) patients receiving chemotherapy have increased risk of life‐threatening venous thromboembolism (VTE). Identifying VTE risk factors may guide thromboprophylaxis in this highly curable population. Methods Data were collected from mGCT patients receiving first‐line platinum‐based chemotherapy at 22 centers. Predefined variables included International Germ Cell Cancer Collaborative Group (IGCCCG) risk classification, long‐axis diameter of largest retroperitoneal lymph node (RPLN), Khorana score, and use of indwelling vascular access device (VAD). VTE occurring at baseline, during chemotherapy and within 90 days, was analyzed. Results Data from 1135 patients were collected. Median age was 31 years (range 10‐74). IGCCCG risk was 64% good, 20% intermediate, and 16% poor. VTE occurred in 150 (13%) patients. RPLN >3.5 cm demonstrated highest discriminatory accuracy for VTE (AUC 0.632, P
Venous thromboembolism can cause morbidity in germ cell tumor patients receiving chemotherapy; large retroperitoneal lymphadenopathy (RPLN) and indwelling vascular access devices (VAD) are significant VTE risk factors. VAD insertion should be avoided and thromboprophylaxis can be considered for large RPLN.
Databáze: OpenAIRE
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