Modeling immunotherapy for allergy
| Autor: | M A, Fishman, L A, Segel |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Pharmacology
General Mathematics General Neuroscience Immunology Models Immunological Insect Bites and Stings Th1 Cells General Biochemistry Genetics and Molecular Biology Th2 Cells Computational Theory and Mathematics Hypersensitivity Animals Humans Pollen Immunotherapy General Agricultural and Biological Sciences Immunologic Memory Mathematics General Environmental Science |
| Zdroj: | Bulletin of Mathematical Biology. 58:1099-1121 |
| ISSN: | 1522-9602 0092-8240 |
| DOI: | 10.1007/bf02458385 |
| Popis: | Type I hypersensitivity, which functions to protect the organism from parasites, is caused by binding of antigen to IgE antibodies pre-attached to the cell surface of tissue mast cells and their circulating counterparts, the basophils. In "allergy," type I hypersensitivity is inappropriately induced by protein-based foreign substances (such as pollen) or protein components of insect stings, which in the normal course of events would be cleared from the organism without causing any damage. Paradoxically, a successful clinical treatment of allergy involves repeated immunization of allergic persons with low doses of the allergen--immunotherapy. Investigation of the available experimental evidence leads to the conclusion that the phenomena of immunotherapy are best addressed in terms of the interplay among the mechanism(s) of immune memory--Th1/Th2 cross-regulation--and the physical compartmentalization of the immune system. These conclusions are illustrated with a numerical simulation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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