Memory for public events in amnestic mild cognitive impairment: The role of hippocampus and ventro-medial prefrontal cortex
| Autor: | Lucia Fadda, Giovanni Augusto Carlesimo, Marco Bozzali, Maria Stefania De Simone, Carlo Caltagirone, Roberta Perri, Laura Serra |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cognitive Neuroscience
Hippocampus Prefrontal Cortex Hippocampal formation Grey matter Neuropsychological Tests Settore MED/26 050105 experimental psychology 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine medicine Humans 0501 psychology and cognitive sciences Cognitive Dysfunction Prefrontal cortex Cognitive impairment Memory Disorders Recall 05 social sciences Significant difference Neuropsychology and Physiological Psychology medicine.anatomical_structure Memory consolidation Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of neuropsychologyReferences. 16(1) |
| ISSN: | 1748-6653 |
| Popis: | BACKGROUND Current theories assume that retrograde memory deficits for semantic information in amnestic mild cognitive impairment (aMCI) are temporally graded and partially sparing most remote memories. Moreover, these models assume a prevalent role of the hippocampus in early phases of memory consolidation and of the prefrontal mesial neocortical areas in permanent consolidation of traces. PURPOSE To explore the relationship between hippocampus and memory accuracy for the most recent public events and between the ventro-medial prefrontal cortex (vmPFC) and memory accuracy irrespective of the memory age, we investigated in aMCI patients the retrograde memory for public events and its relationship with grey matter volume reductions in the hippocampus and vmPFC. METHODS 18 aMCI patients and 13 healthy subjects (HS) underwent a modified version of the Famous Events questionnaire (FEq) to assess their memory performance for public events. Patients underwent 3T-MRI scanning to assess correlations between FEq's scores and grey matter volumes. RESULTS aMCI showed significantly reduced performances on FEq compared to HS in the recollection of most recent events, while no significant difference was observed for more remote memories, thus demonstrating a temporal gradient. Moreover, hippocampal volumes predicted accuracy scores for most recent, but not older, public events. Finally, an area in the subcallosal portion of the vmPFC, corresponding to BA32, predicted accuracy scores on FEq irrespective of the period examined. CONCLUSIONS Pathological changes in a neural circuit linking hippocampal to medial prefrontal cortical regions are responsible for impaired recollection of retrograde memories in aMCI. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text