Alcohol consumption and cause-specific mortality in Cuba: prospective study of 120 623 adults
| Autor: | Noel Rosquete Muñoz, Nazrul Islam, Julie Ann Burrett, Marcy Calderón Martínez, Fernando Achiong Estupiñán, Stephanie Ross, Ismell Alonso Alomá, Mayda Díaz González, Marelis Cendra Asencio, Daniel Martin Simadibrata, Ben Lacey, M. Sofia Massa, Osvaldo Jesús Hernández López, Paul Sherliker, Jennifer L Carter, Richard Peto, José Manuel Morales Rigau, Blake Thomson, Jonathan Emberson, Miguel Morales, Elba Lorenzo-Vázquez, Nurys B. Armas Rojas, Sonia Bess Constantén, Patricia Varona-Pérez, Sarah Lewington |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Research paper
Population Alcohol 01 natural sciences 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Medicine 030212 general & internal medicine 0101 mathematics Mortality Prospective study Prospective cohort study education education.field_of_study lcsh:R5-920 business.industry Proportional hazards model Mortality rate 010102 general mathematics Absolute risk reduction Cause specific mortality Cuba General Medicine chemistry business lcsh:Medicine (General) Alcohol consumption Demography |
| Zdroj: | EClinicalMedicine, Vol 33, Iss, Pp 100692-(2021) EClinicalMedicine |
| ISSN: | 2589-5370 1996-2002 |
| Popis: | Background The associations of cause-specific mortality with alcohol consumption have been studied mainly in higher-income countries. We relate alcohol consumption to mortality in Cuba. Methods In 1996-2002, 146 556 adults were recruited into a prospective study from the general population in five areas of Cuba. Participants were interviewed, measured and followed up by electronic linkage to national death registries until January 1, 2017. After excluding all with missing data or chronic disease at recruitment, Cox regression (adjusted for age, sex, province, education, and smoking) was used to relate mortality rate ratios (RRs) at ages 35–79 years to alcohol consumption. RRs were corrected for long-term variability in alcohol consumption using repeat measures among 20 593 participants resurveyed in 2006-08. Findings After exclusions, there were 120 623 participants aged 35-79 years (mean age 52 [SD 12]; 67 694 [56%] women). At recruitment, 22 670 (43%) men and 9490 (14%) women were current alcohol drinkers, with 15 433 (29%) men and 3054 (5%) women drinking at least weekly; most alcohol consumption was from rum. All-cause mortality was positively and continuously associated with weekly alcohol consumption: each additional 35cl bottle of rum per week (110g of pure alcohol) was associated with ∼10% higher risk of all-cause mortality (RR 1.08 [95%CI 1.05-1.11]). The major causes of excess mortality in weekly drinkers were cancer, vascular disease, and external causes. Non-drinkers had ∼10% higher risk (RR 1.11 [1.09-1.14]) of all-cause mortality than those in the lowest category of weekly alcohol consumption (Interpretation In this large prospective study in Cuba, weekly alcohol consumption was continuously related to premature mortality. Reverse causality is likely to account for much of the apparent excess risk among non-drinkers. The findings support limits to alcohol consumption that are lower than present recommendations in Cuba. Funding Medical Research Council, British Heart Foundation, Cancer Research UK, CDC Foundation (with support from Amgen). |
| Databáze: | OpenAIRE |
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