Cardiac troponin-I: a predictor of prognosis in subarachnoid hemorrhage
| Autor: | Benjamin Atkinson, Preeti Ramappa, Ruth Quah, James D. Marsh, William M. Coplin, Steven Gellman, J. Ricardo Carhuapoma, Deepak Thatai |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Neurology Subarachnoid hemorrhage Multivariate analysis Critical Care and Intensive Care Medicine Medical Records Predictive Value of Tests Internal medicine Troponin I Medicine Humans Glasgow Coma Scale cardiovascular diseases Hospital Mortality Aged biology business.industry Medical record Incidence Odds ratio Middle Aged Subarachnoid Hemorrhage medicine.disease Prognosis Troponin Surgery Logistic Models Multivariate Analysis biology.protein Cardiology Female Neurology (clinical) business Biomarkers |
| Zdroj: | Neurocritical care. 8(3) |
| ISSN: | 1541-6933 |
| Popis: | Release of cardiac biomarkers is reported in patients with subarachnoid hemorrhage (SAH). Data addressing the impact of cardiac injury on outcome in these patients is sparse. This study was conducted to ascertain the association of elevation of serum cardiac Troponin-I (cTnI) with mortality and neurological outcome in patients with SAH. Medical records of all patients admitted with a diagnosis of SAH and at least one measured cTnI were reviewed. Demographic and clinical variables including admission neurological status were collected. Conservative and non-parametric statistics were used to assess association between cTnI and death or neurological outcome at discharge. The study group comprised of 83 patients with a mean age of 59 years. There was a female (60%) and African-American (60%) preponderance. At admission, the median Glasgow Coma Scale (GCS) was 9, and 47% had a severe Hunt–Hess grade (HHG) of ≥4. Elevation of cTnI was found in 31 (37%) patients and was associated with worse baseline Fisher grade (p=0.01) and neurological status: GCS score (p=0.006) and HHG (p=0.007). Patients with abnormal cTnI were more likely to die (55% vs.27%; odds ratio 1.3–8.4, p = 0.01) and had a worse GCS score (p = 0.008) and HHG (p = 0.004) on discharge. On multivariate analysis, peak cTnI (p = 0.04) and admission GCS score of |
| Databáze: | OpenAIRE |
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