Advances in preclinical hematopoietic stem cell models and possible implications for improving therapeutic transplantation

Autor: Maria Feliz Norberto, Kathryn S. Potts, Teresa V. Bowman, Bianca A. Ulloa, Ellen Fraint
Rok vydání: 2020
Předmět:
Primates
0301 basic medicine
graft‐vs‐host disease
Transplantation Conditioning
medicine.medical_treatment
ved/biology.organism_classification_rank.species
Graft vs Host Disease
Disease
Hematopoietic stem cell transplantation
Bioinformatics
Mice
03 medical and health sciences
lineage tracing
0302 clinical medicine
Tissue‐specific Progenitor and Stem Cells
Cell dose
Animals
Medicine
lcsh:QH573-671
Model organism
Zebrafish
lcsh:R5-920
Concise Review
lcsh:Cytology
business.industry
ved/biology
Hematopoietic Stem Cell Transplantation
Hematopoietic stem cell
Cell Biology
General Medicine
preclinical models
hematopoietic stem cells
Transplantation
Disease Models
Animal
surgical procedures
operative
030104 developmental biology
medicine.anatomical_structure
Stem cell
lcsh:Medicine (General)
business
030217 neurology & neurosurgery
Ex vivo
transplantation
Developmental Biology
Zdroj: Stem Cells Translational Medicine, Vol 10, Iss 3, Pp 337-345 (2021)
Stem Cells Translational Medicine
ISSN: 2157-6580
2157-6564
DOI: 10.1002/sctm.20-0294
Popis: Hematopoietic stem cell transplantation (HSCT) is a treatment for many malignant, congenital, and acquired hematologic diseases. Some outstanding challenges in the HSCT field include the paucity of immunologically‐matched donors, our inability to effectively expand hematopoeitic stem cells (HSCs) ex vivo, and the high infection risk during engraftment. Scientists are striving to develop protocols to generate, expand, and maintain HSCs ex vivo, however these are not yet ready for clinical application. Given these problems, advancing our understanding of HSC specification, regulation, and differentiation in preclinical models is essential to improve the therapeutic utility of HSCT. In this review, we link biomedical researchers and transplantation clinicians by discussing the potential therapeutic implications of recent fundamental HSC research in model organisms. We consider deficiencies in current HSCT practice, such as problems achieving adequate cell dose for successful and rapid engraftment, immense inflammatory cascade activation after myeloablation, and graft‐vs‐host disease. Furthermore, we discuss recent advances in the field of HSC biology and transplantation made in preclinical models of zebrafish, mouse, and nonhuman primates that could inform emerging practice for clinical application.
Clinical (established) and preclinical (theoretical) advances are informing treatment options for circumventing current hematopoietic stem cell transplantation (HSCT) limitations including post‐transplant infection, low HSC donor supply, inflammation, and graft‐vs‐host disease (GVHD). This review covers the advances in preclinical hematopoietic stem cell models and possible implications for improving therapeutic transplantation.
Databáze: OpenAIRE
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