Self-powered implantable electronic-skin for in situ analysis of urea/uric-acid in body fluids and the potential applications in real-time kidney-disease diagnosis
| Autor: | Shuai Wang, Lili Xing, Xinyu Xue, Yan Zhang, Huiling Gao, Linlin Zhang, Wenyan Yang, Wuxiao Han |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Materials science
Biocompatibility Electronic skin 02 engineering and technology Biosensing Techniques 010402 general chemistry 01 natural sciences chemistry.chemical_compound Mice Electric Power Supplies Implants Experimental Animals Humans Urea General Materials Science Abdominal skin Nanowires 021001 nanoscience & nanotechnology 0104 chemical sciences Body Fluids Uric Acid Mice Inbred C57BL Chronic disease chemistry In situ analysis Uric acid Kidney Diseases Zinc Oxide 0210 nano-technology Biosensor Biomedical engineering |
| Zdroj: | Nanoscale. 10(4) |
| ISSN: | 2040-3372 |
| Popis: | As the concentration of different biomarkers in human body fluids are an important parameter of chronic disease, wearable biosensors for in situ analysis of body fluids with high sensitivity, real-time detection, flexibility and biocompatibility have significant potential therapeutic applications. In this paper, a flexible self-powered implantable electronic-skin (e-skin) for in situ body fluids analysis (urea/uric-acid) as a real-time kidney-disease diagnoser has been proposed based on the piezo-enzymatic-reaction coupling process of ZnO nanowire arrays. It can convert the mechanical energy of body movements into a piezoelectric impulse, and the outputting piezoelectric signal contains the urea/uric-acid concentration information in body fluids. This piezoelectric-biosensing process does not need an external electricity supply or battery. The e-skin was implanted under the abdominal skin of a mouse and provided in situ analysis of the kidney-disease parameters. These results provide a new approach for developing a self-powered in situ body fluids-analysis technique for chronic-disease diagnosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|