A highly divergent HIV-2-related isolate
| Autor: | Herbert Kühnel, Anja Seipp, Michalina Adamski, Helga Rübsamen-Waigmann, Renate Kreutz, Ursula Dietrich |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Genes
Viral viruses animal diseases Molecular Sequence Data Human immunodeficiency virus (HIV) Biology medicine.disease_cause Ghana Virus Viral Proteins Viral envelope Phylogenetics medicine Humans Genetics chemistry.chemical_classification Multidisciplinary Base Sequence Nucleic acid sequence Genetic Variation virus diseases Simian immunodeficiency virus biology.organism_classification Biological Evolution Virology Molecular Weight chemistry HIV-2 Sooty mangabey Electrophoresis Polyacrylamide Gel Female Simian Immunodeficiency Virus Glycoprotein |
| Zdroj: | Nature. 342:948-950 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/342948a0 |
| Popis: | It has been suggested that the human immunodeficiency virus type 2 (HIV-2) and the simian immunodeficiency virus from rhesus macaques (SIVmac) evolved from the sooty mangabey virus SIVsm (ref. 1). We now describe an HIV-2-related isolate, HIV-2-D205, from a healthy Ghanaian woman that is genetically equidistant to the prototypic HIV-2 strains and to SIVsm and SIVmac. Supported by the observation that HIV-2D205 differs in a step of envelope glycoprotein processing, our data indicate that it could represent an alternative HIV-2 subtype and that viruses of the HIV-2/SIVsm/SIVmac group could have already infected humans before HIV-2 and SIVsm/SIVmac diverged. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|