Wechsler subscale IQ and subtest profile in early treated phenylketonuria
| Autor: | Nicolas Fay, P.V. Griffiths, C. Demellweek, D.C. Davidson, P.H. Robinson |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Phenylketonurias Phenylalanine Child Rearing Predictive Value of Tests medicine Humans Psychiatry Child Wechsler Intelligence Scale for Children Retrospective Studies Intelligence quotient Child rearing business.industry Wechsler Scales Wechsler Adult Intelligence Scale Infant Verbal reasoning Flynn effect El Niño Socioeconomic Factors Community Child Health Public Health and Epidemiology Child Preschool Pediatrics Perinatology and Child Health business Biomarkers Clinical psychology |
| Zdroj: | Archives of disease in childhood. 82(3) |
| ISSN: | 1468-2044 |
| Popis: | AIM—Mildly depressed IQ is common in treated phenylketonuria. This study explored whether a particular intellectual ability profile typifies early and continuously treated phenylketonuria and whether component skills comprising the IQ relate to socioeconomic and treatment factors. METHODS—IQ scores were collected retrospectively from variants of the "Wechsler intelligence scale for children" performed at age 8 on 57 children with early treated, classic phenylketonuria. The mental ability pattern underlying IQ was investigated by analysing subscale and subtest scores and dietary factors, such as historical phenylalanine blood concentrations. RESULTS—The children's mean full scale IQ of 91.11 was significantly below the healthy population norm. There was a significant discrepancy between their mean verbal IQ (94.65) and mean performance IQ (89.42), suggestive of a spatial deficit, but the data did not support a biochemical or sociological explanation. Individual Wechsler subtests had no distinctive pattern. Phenylalanine control at age 2 was predictive of overall IQ. At this age, children with annual median phenylalanine < 360 µmol/litre (recommended UK upper limit) had a mean IQ 10 points higher than those above. CONCLUSIONS—Early and continuous treatment of phenylketonuria does not necessarily lead to normalisation of overall IQ. Verbal intelligence in the primary school years appears to normalise if blood phenylalanine is maintained below 360 µmol/litre in infancy, but spatial intelligence may remain poor. However, the discrepancy in skill development is not the result of social status or treatment variables. Perhaps weak spatial intelligence is an ancillary effect of a protective rearing style occasioned by the dietary treatment regimen. |
| Databáze: | OpenAIRE |
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