Utility of near-infrared spectroscopy for detection of thin-cap neoatherosclerosis
| Autor: | Wojciech Wojakowski, Emmanouil S. Brilakis, Gary S. Mintz, Gregg W. Stone, Akiko Maehara, Martin B. Leon, Ziad A. Ali, Ajay J. Kirtane, Tomasz Roleder, Keyvan Karimi Galougahi, Navdeep Bhatti, Tamim Nazif, Chee Yang Chin, Dimitri Karmpaliotis |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Pathology genetic structures Treatment outcome Coronary Artery Disease 030204 cardiovascular system & hematology Severity of Illness Index Cohort Studies 0302 clinical medicine Restenosis 030212 general & internal medicine Angioplasty Balloon Coronary Observer Variation Spectroscopy Near-Infrared medicine.diagnostic_test Fibrous cap Drug-Eluting Stents General Medicine Middle Aged Prognosis surgical procedures operative medicine.anatomical_structure Treatment Outcome Female Cardiology and Cardiovascular Medicine Observer variation Tomography Optical Coherence medicine.medical_specialty Risk Assessment 03 medical and health sciences Optical coherence tomography Predictive Value of Tests Neointima medicine Humans Radiology Nuclear Medicine and imaging Aged Retrospective Studies Analysis of Variance business.industry Near-infrared spectroscopy technology industry and agriculture Original Articles equipment and supplies medicine.disease Survival Analysis Coronary arteries Logistic Models ROC Curve sense organs In stent restenosis business Nuclear medicine |
| Popis: | Near-infrared spectroscopy (NIRS) has been employed to assess the composition of the atherosclerotic plaques in native coronary arteries. However, little is known about the detection of neoatherosclerosis by NIRS in in-stent restenosis (ISR). The aim of the study was to assess the relationship between the distribution of lipid determined by NIRS and morphology of ISR on optical coherence tomography (OCT).We performed both NIRS and OCT in 39 drug-eluting stents with ISR. Values of lipid-core burden index (LCBI) derived by NIRS were compared with the OCT-derived thickness of the fibrous cap covering neoatherosclerotic lesions. A total of 22 (49%) in-stent neointimas were identified as lipid rich by both NIRS and OCT. There was good agreement between OCT and NIRS in identifying lipid within in-stent neointima (kappa = 0.60, 95% CI: 0.34-0.86). OCT identified thin-cap neoatheromas (TCNA) (65 µm) in 12 stents (23%). The minimal cap thickness of in-stent neoatherosclerotic plaque measured by OCT correlated with the maxLCBI4mm (maximal LCBI per 4 mm) within the stent (r = -0.77, P0.01). Moreover, maxLCBI4mm was able to accurately predict TCNA with a cut-off value of144.NIRS correlates with OCT identification of lipids in stented vessels and is able to predict the presence of thin fibrous cap neoatheroma. |
| Databáze: | OpenAIRE |
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