Facile Synthesis of Ligand-Free Iridium Nanoparticles and Their In Vitro Biocompatibility
Autor: | Hayden Winter, Andrea M. Goforth, Gaurav Sahay, Anna L. Brown, Conroy Sun |
---|---|
Rok vydání: | 2018 |
Předmět: |
Surface characterization
Materials science Biocompatibility Reducing agent Nanochemistry Nanoparticle chemistry.chemical_element 02 engineering and technology 010402 general chemistry Borohydride Iridium 01 natural sciences Chloride chemistry.chemical_compound medicine lcsh:TA401-492 General Materials Science Nanoparticle synthesis Aqueous solution Nano Express 021001 nanoscience & nanotechnology Condensed Matter Physics Cellular toxicity 0104 chemical sciences Nanocrystals chemistry lcsh:Materials of engineering and construction. Mechanics of materials 0210 nano-technology medicine.drug Nuclear chemistry |
Zdroj: | Nanoscale Research Letters Nanoscale Research Letters, Vol 13, Iss 1, Pp 1-6 (2018) |
ISSN: | 1931-7573 |
Popis: | High-density inorganic nanoparticles have shown promise in medical applications that utilize radiation including X-ray imaging and as radiation dose enhancers for radiotherapy. We have developed an aqueous synthetic method to produce small (~ 2 nm) iridium nanoparticles (IrNPs) by reduction of iridium(III) chloride using a borohydride reducing agent. Unlike other solution-based synthesis methods, uniform and monodispersed IrNPs are produced without the use of surfactants or other solubilizing ligands. These nanoparticles are highly crystalline as observed by X-ray diffraction and high-resolution transmission electron microscopy (TEM). In vitro metabolic toxicity assays using hepatocyte and macrophage cells demonstrate that both IrNPs and iridium(III) chloride are well tolerated at concentrations of up to 10 μM iridium. Furthermore, the IrNPs were assessed in a hemolytic assay and found to have no significant impact on red blood cells when exposed to concentrations up to 100 μM. Overall, these results support the potential for the in vivo application of this nanomaterial. Electronic supplementary material The online version of this article (10.1186/s11671-018-2621-3) contains supplementary material, which is available to authorized users. |
Databáze: | OpenAIRE |
Externí odkaz: |