An immunotherapeutic approach to decipher the role of long non-coding RNAs in cancer progression, resistance and epigenetic regulation of immune cells
| Autor: | Wuling Liu, Hemavathi Dhandapani, Xiangchun Shen, Krishnapriya M. Varier, Yaacov Ben-David, Jialei Song, Anling Hu, Babu Gajendran, Chunlin Wang, Yanmei Li |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_treatment animal diseases chemical and pharmacologic phenomena Adaptive and innate immune cells Review Biology Epigenesis Genetic Transcriptome 03 medical and health sciences 0302 clinical medicine Immune system Neoplasms Gene expression medicine Autophagy Humans Epigenetics LncRNAs RC254-282 Innate immune system Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens Immunotherapy biochemical phenomena metabolism and nutrition medicine.disease 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer research Disease Progression bacteria RNA Long Noncoding |
| Zdroj: | Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-18 (2021) Journal of Experimental & Clinical Cancer Research : CR |
| ISSN: | 1756-9966 |
| Popis: | Immunotherapeutic treatments are gaining attention due to their effective anti-tumor response. Particularly, the revolution of immune checkpoint inhibitors (ICIs) produces promising outcomes for various cancer types. However, the usage of immunotherapy is limited due to its low response rate, suggesting that tumor cells escape the immune surveillance. Rapid advances in transcriptomic profiling have led to recognize immune-related long non-coding RNAs (LncRNAs), as regulators of immune cell-specific gene expression that mediates immune stimulatory as well as suppression of immune response, indicating LncRNAs as targets to improve the efficacy of immunotherapy against tumours. Moreover, the immune-related LncRNAs acting as epigenetic modifiers are also under deep investigation. Thus, herein, is a summarised knowledge of LncRNAs and their regulation in the adaptive and innate immune system, considering their importance in autophagy and predicting putative immunotherapeutic responses. |
| Databáze: | OpenAIRE |
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