[Amyotrophic lateral sclerosis with muscle weakness and dropped head during the course of Parkinson's disease: an autopsy case]
| Autor: | Noriko Nishikawa, Michita Mikasa, Shinji Oda, Masaki Takao, Terunori Sano, Yuji Takahashi |
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| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty Parkinson's disease Palliative care Muscle Weakness business.industry Amyotrophic Lateral Sclerosis Muscle weakness Parkinson Disease Disease Middle Aged medicine.disease Spinal cord Paresis medicine.anatomical_structure Respiratory failure medicine Humans Female Neurology (clinical) Brainstem Autopsy Amyotrophic lateral sclerosis medicine.symptom business |
| Zdroj: | Rinsho shinkeigaku = Clinical neurology. 61(6) |
| ISSN: | 1882-0654 |
| Popis: | A 64-year-old female developed Parkinson's disease at the age of 52 years. She experienced muscle weakness in the upper right extremities and dropped head at 62 and 63 years, respectively; both symptoms were considered to be associated with Parkinson's disease (PD). The dosage of L-DOPA was increased from 200 mg/day to 900 mg/day; however, her neurological symptoms did not improve. Eventually, she was diagnosed with amyotrophic lateral sclerosis (ALS) at 64 years. She was placed under palliative care, and died of respiratory failure and malnutrition. Neuropathologic findings were consistent with the coexistence of PD and ALS. In fact, there were α-synuclein immunoreactive Lewy bodies (Braak stage 4) as well as TDP-43 immunoreactive deposits in the motor nuclei at the level of brainstem and spinal cord. Therefore, coexisting pathologies must be taken into account in a patient showing multi-system symptoms. |
| Databáze: | OpenAIRE |
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