Adult Autoimmune Enteropathy Treated Successfully with Tacrolimus
| Autor: | Wolfgang Schmidt, Ergun Sahin, Ernst-Otto Riecken, Martin Zeitz, Bernhard Heine, Severin Daum, Andreas Jansen |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
Autoimmune disease Chemotherapy Duodenum business.industry medicine.medical_treatment Gastroenterology Administration Oral Middle Aged Autoimmune enteropathy medicine.disease Tacrolimus Autoimmune Diseases Intestinal Diseases Chronic disease Immunopathology Immunology medicine Humans business Immunosuppressive Agents |
| Zdroj: | Digestion. 68:86-90 |
| ISSN: | 1421-9867 0012-2823 |
| Popis: | Background: Autoimmune enteropathy is a life-threatening, chronic disease of the small bowel mucosa, which generally responds well to steroids. Treatment requires long-term immunosuppression, and steroid-sparing treatment strategies are desirable. Azathioprine and cyclosporine A have limitations, however alternatives have not been described in adults. Case Report: We present the case of a 54-year-old male patient with autoimmune enteropathy who responded initially to a standard treatment with steroids, but was dependent on 30 mg prednisolone. Medical treatment was changed to tacrolimus after renal function deteriorated under treatment with cyclosporine A. Under this regimen, small bowel histology normalized and the clinical condition is stable after 2 years of introduction of tacrolimus. Conclusion: This constitutes the first report of effective treatment of adult autoimmune enteropathy with tacrolimus, a substance with a similar mode of action to cyclosporine, but with fewer side effects and improved bioavailability. |
| Databáze: | OpenAIRE |
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