Cytotoxicity study of plasma-sprayed hydroxyapatite coating on high nitrogen austenitic stainless steels
| Autor: | C. P. O. Ossa, Sizue Ota Rogero, André Paulo Tschiptschin |
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| Rok vydání: | 2005 |
| Předmět: |
Materials science
Nitrogen Biomedical Engineering Biophysics chemistry.chemical_element Bioengineering Bone tissue Osseointegration Corrosion Biomaterials Mice Coated Materials Biocompatible Cell Line Tumor medicine Pitting corrosion Animals Austenite fungi Metallurgy technology industry and agriculture Intergranular corrosion Stainless Steel Nickel medicine.anatomical_structure Durapatite chemistry Neutral Red Crevice corrosion |
| Zdroj: | Journal of materials science. Materials in medicine. 17(11) |
| ISSN: | 0957-4530 |
| Popis: | Stainless steel has been frequently used for temporary implants but its use as permanent implants is restricted due to its low pitting corrosion resistance. Nitrogen additions to these steels improve both mechanical properties and corrosion resistance, particularly the pitting and crevice corrosion resistance. Many reports concerning allergic reactions caused by nickel led to the development of nickel free stainless steel; it has excellent mechanical properties and very high corrosion resistance. On the other hand, stainless steels are biologically tolerated and no chemical bonds are formed between the steel and the bone tissue. Hydroxyapatite coatings deposited on stainless steels improve osseointegration, due their capacity to form chemical bonds (bioactive fixation) with the bone tissue. In this work hydroxyapatite coatings were plasma-sprayed on three austenitic stainless steels: ASTM-F138, ASTM-F1586 and the nickel-free Bohler-P558. The coatings were analyzed by SEM and XDR. The cytotoxicity of the coatings/steels was studied using the neutral red uptake method by quantitative evaluation of cell viability. The three uncoated stainless steels and the hydroxyapatite coated Bohler-P558 did not have any toxic effect on the cell culture. The hydroxyapatite coated ASTM-F138 and ASTM-F1586 stainless steels presented cytotoxicity indexes (IC50%) lower than 50% and high nickel contents in the extracts. |
| Databáze: | OpenAIRE |
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