A Critical Review of Properties and Analytical Methods for the Determination of Oxytetracyline in Biological and Pharmaceutical Matrices
| Autor: | Gilmar Hanck da Silva, Mariza Aires Fernandes, Marlus Chorilli, Josimar O. Eloy, Felipe Tita de Lima, Lucas Noboru Fatori Trevizan |
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| Rok vydání: | 2016 |
| Předmět: |
Drug
media_common.quotation_subject Oxytetracycline 02 engineering and technology Pharmacology 01 natural sciences Analytical Chemistry chemistry.chemical_compound Biological property Animals Humans Curcuma Chromatography High Pressure Liquid media_common Aqueous medium biology Chemistry Natural compound 010401 analytical chemistry 021001 nanoscience & nanotechnology biology.organism_classification 0104 chemical sciences Bioavailability Anti-Bacterial Agents Pharmaceutical Preparations Drug delivery Curcumin 0210 nano-technology |
| Zdroj: | Critical reviews in analytical chemistry. 47(2) |
| ISSN: | 1547-6510 |
| Popis: | Curcumin, a natural compound extracted from turmeric (Curcuma longa), has been extensively studied because of its various pharmacological properties, such as anti-inflammatory, antioxidant, antibiotic, antiprotozoal, immunomodulatory, anti-proliferative, antitumor, and anticarcinogenic effects. However, low solubility in aqueous media has limited its therapeutic applications. To overcome these bioavailability issues, the use of drug delivery systems providing localized or targeted delivery of this drug may represent a more viable therapeutic option. Several drug delivery systems have been shown to significantly enhance the therapeutic efficacy of curcumin. Additionally, a wide variety of analytical methods are available for the qualitative and quantitative analysis of curcumin in different matrices, including plant extracts, biological fluids, and drug delivery systems. There are a variety of methodologies to quantify curcumin, but chromatographic and spectroscopic techniques are the ones most commonly used. Thus, in this review, we evaluate the biological properties of curcumin, as well as its nanotechnology-based delivery systems and methods of analysis. |
| Databáze: | OpenAIRE |
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