Neural and subjective effects of inhaled N,N-dimethyltryptamine in natural settings
| Autor: | Christopher Timmermann, Mauricio Arias, Carla Pallavicini, Enzo Tagliazucchi, Federico Cavanna, Yonatan Sanz Perl, Yayla Ilksoy, Laura de la Fuente, Celeste Romero, Robin L. Carhart-Harris, Federico Zamberlan |
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| Rok vydání: | 2021 |
| Předmět: |
Tryptamine
Adult Male Subjective effects Personality Inventory Psychometrics Biological Availability Pharmacology Relaxation Therapy chemistry.chemical_compound N N-Dimethyltryptamine Administration Inhalation Outcome Assessment Health Care medicine Humans Pharmacology (medical) Electroencephalography Self Concept Tryptamines Psychiatry and Mental health chemistry Hallucinogens Consciousness Disorders Female Self Report Drug Monitoring Psychology Wireless Technology medicine.drug Mysticism |
| Zdroj: | Journal of psychopharmacology (Oxford, England). 35(4) |
| ISSN: | 1461-7285 |
| Popis: | Background: N,N-dimethyltryptamine is a short-acting psychedelic tryptamine found naturally in many plants and animals. Few studies to date have addressed the neural and psychological effects of N,N-dimethyltryptamine alone, either administered intravenously or inhaled in freebase form, and none have been conducted in natural settings. Aims: Our primary aim was to study the acute effects of inhaled N,N-dimethyltryptamine in natural settings, focusing on questions tuned to the advantages of conducting field research, including the effects of contextual factors (i.e. “set“ and “setting“), the possibility of studying a comparatively large number of subjects, and the relaxed mental state of participants consuming N,N-dimethyltryptamine in familiar and comfortable settings. Methods: We combined state-of-the-art wireless electroencephalography with psychometric questionnaires to study the neural and subjective effects of naturalistic N,N-dimethyltryptamine use in 35 healthy and experienced participants. Results: We observed that N,N-dimethyltryptamine significantly decreased the power of alpha (8–12 Hz) oscillations throughout all scalp locations, while simultaneously increasing power of delta (1–4 Hz) and gamma (30–40 Hz) oscillations. Gamma power increases correlated with subjective reports indicative of some features of mystical-type experiences. N,N-dimethyltryptamine also increased global synchrony and metastability in the gamma band while decreasing those measures in the alpha band. Conclusions: Our results are consistent with previous studies of psychedelic action in the human brain, while at the same time the results suggest potential electroencephalography markers of mystical-type experiences in natural settings, thus highlighting the importance of investigating these compounds in the contexts where they are naturally consumed. |
| Databáze: | OpenAIRE |
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