Potent and Non-Cytotoxic Antibacterial Compounds Against Methicillin-Resistant Staphylococcus aureus Isolated from Psiloxylon mauritianum, A Medicinal Plant from Reunion Island
| Autor: | Elsa Van Elslande, Amandine André, Didier Stien, Jonathan Sorres, Véronique Eparvier |
|---|---|
| Přispěvatelé: | Institut de Chimie des Substances Naturelles (ICSN), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Biodiversité et Biotechnologies Microbiennes (LBBM), PIERRE FABRE-EDF (EDF)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Observatoire océanologique de Banyuls (OOB), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Staphylococcus aureus
Phloroglucinol Ethyl acetate Pharmaceutical Science Psiloxylon [CHIM.THER]Chemical Sciences/Medicinal Chemistry 010403 inorganic & nuclear chemistry medicine.disease_cause 01 natural sciences Psiloxylon mauritianum Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound acylphloroglucinol lcsh:Organic chemistry Drug Discovery medicine Physical and Theoretical Chemistry Cytotoxicity Traditional medicine biology 010405 organic chemistry Organic Chemistry Biological activity antibacterial compounds biology.organism_classification Methicillin-resistant Staphylococcus aureus 0104 chemical sciences chemistry Chemistry (miscellaneous) [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology Molecular Medicine Antibacterial activity Aspidin derivatives |
| Zdroj: | Molecules Molecules, MDPI, 2020, 25 (16), pp.3565. ⟨10.3390/molecules25163565⟩ Molecules, Vol 25, Iss 3565, p 3565 (2020) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules25163565⟩ |
| Popis: | With the occurrence of antibiotic-resistant Staphylococcus aureus strains, identification of new anti-staphylococcal drugs has become a necessity. It has long been demonstrated that plants are a large and diverse source of antibacterial compounds. Psiloxylon mauritianum, an endemic medicinal plant from Reunion Island, was chemically investigated for its reported biological activity against S. aureus. Aspidin VB, a phloroglucinol derivative never before described, together with Aspidin BB, were first isolated from the ethyl acetate extract of P. mauritianum leaves. Their structures were elucidated from spectroscopic data. Aspidin VB exhibited strong antibacterial activity against standard and methicillin-resistant S. aureus strains, with a minimal inhibition concentration (MIC) of 0.25 μg/mL, and no cytotoxicity was observed at 10−5 M in MRC5 cells. Due to its biological activities, Aspidin VB appears to be a good natural lead in the fight against S. aureus. |
| Databáze: | OpenAIRE |
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