Prenatal factors associated with the development of eczema in the first year of life
| Autor: | Margaret Kurzius-Spencer, Marilyn Halonen, Fernando D. Martinez, Anne L. Wright, I. Carla Lohman |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Immunology Eczema Common Cold Mothers Immunoglobulin E Umbilical cord Cohort Studies Atopy Pregnancy Risk Factors Surveys and Questionnaires otorhinolaryngologic diseases medicine Humans Immunology and Allergy Prospective Studies Asthma biology Obstetrics business.industry Arizona Infant Atopic dermatitis medicine.disease medicine.anatomical_structure Prenatal Exposure Delayed Effects Cord blood Pediatrics Perinatology and Child Health biology.protein Regression Analysis Female business Cohort study |
| Zdroj: | Pediatric Allergy and Immunology. 16:19-26 |
| ISSN: | 1399-3038 0905-6157 |
| DOI: | 10.1111/j.1399-3038.2005.00233.x |
| Popis: | Prenatal factors have been implicated in childhood eczema, but the relationship between maternal cytokine production during pregnancy and infant eczema is unknown. Non-selected women in their third trimester were enrolled in the Tucson Infant Immune Study. Data from three sources were used to define MD-eczema: parent-completed illness questionnaires at age 2, 3, 4, 6 and 9 months regarding physician-seen eczema, parent-completed questionnaires at 12 months regarding physician-diagnosed eczema, and medical record reviews. Blood samples were taken from mothers during their third trimester and from the umbilical cord at birth. Maternal peripheral blood mononuclear cells and cord blood mononuclear cells were stimulated with ConA/PMA, and supernatants were assayed for IFN-gamma and IL-4, -5, -10, and -13. Of 364 children, 28% were seen by a physician for eczema by 1 yr of age. After adjustment for potential confounders using logistic regression, the odds for development of eczema in infancy were significantly higher when mothers had active eczema in pregnancy (OR, 2.46, CI 1.0-5.8, p |
| Databáze: | OpenAIRE |
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