Computed Tomography-Guided Biopsy for Small (≤20 mm) Lung Nodules: A Meta-Analysis
| Autor: | Yi Liu, Shao-Qing Wang, Guang-Sheng Liu, Yu-Fei Fu, Hui-Ling Liu, Yi-Bing Shi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Image-Guided Biopsy
medicine.medical_specialty Lung Neoplasms Lung biopsy Cochrane Library Radiography Interventional 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Biopsy medicine Humans Radiology Nuclear Medicine and imaging Lung medicine.diagnostic_test business.industry Reproducibility of Results Solitary Pulmonary Nodule Publication bias Random effects model medicine.disease Pneumothorax Meta-analysis Radiology Complication business Tomography X-Ray Computed 030217 neurology & neurosurgery |
| Zdroj: | Journal of computer assisted tomography. 44(6) |
| ISSN: | 1532-3145 |
| Popis: | Purpose This study was designed to evaluate the diagnostic accuracy of computed tomography (CT)-guided biopsy for small lung nodules (SLNs) (≤20 mm) and to assess related complication rates. Methods We reviewed the Pubmed, Embase, and Cochrane Library databases to identify all relevant studies published as of April 2020. Random effects modeling were then used to evaluate pooled data pertaining to technical success rates, diagnostic accuracy, pneumothorax rates, and rates of hemoptysis. The meta-analysis was conducted using Stata v12.0. Results In total, we identified 25 relevant studies for incorporation into this meta-analysis, incorporating 2922 total CT-guided lung biopsy. Pooled technical success rates, diagnostic accuracy, pneumothorax rates, and hemoptysis rates were 94% (95% confidential interval [CI], 0.91-0.98), 90% (95% CI, 0.88-0.93), 19% (95% CI:, 0.15-0.24), and 12% (95% CI, 0.08-0.15), respectively. We observed significant heterogeneity among these studies for all 4 of these parameters (I = 90.0%, 82.7%, 88.6%, and 88.4%, respectively). When we conducted a meta-regression analysis, we did not identify any variables that influenced diagnostic accuracy or technical success, pneumothorax, or hemoptysis rates. Publication bias risk analyses suggested that there was relatively little risk of publication bias pertaining to pneumothorax rates (P = 0.400) or hemoptysis rates (P = 0.377). In contrast, we detected a high risk of publication bias pertaining to reported technical success rates (P = 0.007) and diagnostic accuracy (P = 0.000). Conclusions A CT-guided biopsy can be safely and effectively used to diagnose SLNs. |
| Databáze: | OpenAIRE |
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