A facile preparation method for nanosized MOFs as a multifunctional material for cellular imaging and drug delivery
| Autor: | Kimoon Kim, Hyunuk Kim, Kyeng Min Park, Jaehyoung Koo, James Brooke Murray |
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| Rok vydání: | 2016 |
| Předmět: |
Aqueous solution
Chemistry fungi Biomaterial Nanoparticle Nanotechnology 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Endocytosis 01 natural sciences 0104 chemical sciences Nanomaterials Colloid Pulmonary surfactant Drug delivery 0210 nano-technology |
| Zdroj: | Supramolecular Chemistry. 29:441-445 |
| ISSN: | 1029-0478 1061-0278 |
| Popis: | Tb-based metal-organic framework nanoparticles (Tb-MOF NPs) with good colloidal stability and stable fluorescence properties in an aqueous solution were prepared by a simple mechanical grinding of Tb-MOF with a biocompatible polymer surfactant (F127). The characteristic fluorescence property of Tb-MOF NPs allowed us to use this nanomaterial as a cell imaging probe. Efficient cellular uptake of Tb-MOF NPs apparently via an energy-dependent endocytosis was observed by confocal laser scanning microscopy. By taking advantage of the porous nature of the Tb-MOF NPs an anticancer drug (doxorubicin) was successfully loaded and delivered to kill cancer cells to demonstrate their usage as a drug delivery vehicle. This simple grinding method afforded a nanosized, multifunctional biomaterial that was used for cell imaging and drug delivery, and it can be extended to other MOFs to widen their applications. |
| Databáze: | OpenAIRE |
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